Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice

Progress in Neuro-psychopharmacology & Biological Psychiatry
Flavia T ClaroR H Silva

Abstract

This study verifies the effects of bovine brain phosphatidylserine (PS) on passive avoidance (PA) and contextual fear conditioning (CFC) tests in scopolamine-treated mice. Mice received daily i.p. 50 mg/kg PS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. On day 6, mice received saline (TRIS-SAL and PS-SAL) or 1 mg/kg SCO (TRIS-SCO and PS-SCO) i.p. After 20 min, the animals were submitted to PA (experiment 1) or CFC (experiment 2) training sessions, and tests were performed 24 h later. Latency in entering the dark chamber of the PA apparatus presented by TRIS-SCO (but not PS-SCO) group in the test was significantly higher than those presented by controls. Except for TRIS-SCO, all the groups presented higher latencies in the test compared to the training session. In experiment 2, the TRIS-SCO (but not PS-SCO) group presented significantly lower freezing duration than that presented by the TRIS-SAL group in the test. Animals treated with PS alone presented higher freezing duration than that presented by the TRIS-SAL group. The results demonstrate that PS attenuates SCO-induced amnesia in both PA and CFC tests. In addition, PS per se improves retention in the CFC test.

References

Apr 1, 1988·Journal of the Neurological Sciences·A W ProcterD M Bowen
Sep 1, 1988·Neurobiology of Aging·F H GageD Armstrong
Jan 1, 1986·Psychopharmacology·A ZanottiG Toffano
May 1, 1985·Behavioral and Neural Biology·C A Netto, I Izquierdo
Mar 1, 1986·Neurobiology of Aging·F AportiL Goldstein
Jan 1, 1981·Neurobiology of Aging·F DragoU Scapagnini
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Apr 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·E A Van der Zee, B R Douma
Nov 5, 1999·Physiology & Behavior·F T ClaroR Frussa-Filho
Sep 12, 2000·European Journal of Pharmacology·C S AlvesM A Vital
Feb 28, 2002·Psychopharmacology·R H SilvaR Frussa-Filho
May 9, 2002·Behavioural Brain Research·Regina H SilvaRoberto Frussa-Filho
Dec 7, 2002·Life Sciences·Regina H Silva, Roberto Frussa-Filho
Jan 28, 2004·European Journal of Pharmacology·Juliana Cini PerryMaria A B F Vital
Jul 28, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·João C CastilhoMaria A B F Vital
Dec 4, 2004·Behavioural Pharmacology·M B CalzavaraR Frussa-Filho

❮ Previous
Next ❯

Citations

May 6, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nachum Vaisman, Dori Pelled
Jul 25, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bombi LeeDae-Hyun Hahm
Mar 25, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·André de Macêdo MedeirosRegina Helena Silva
Nov 13, 2012·Journal of Biotechnology·Zhang-Qun Duan, Fei Hu
Jul 9, 2016·Behavioural Pharmacology·Teresa A BarberShawn A Gessay
Mar 23, 2018·Frontiers in Aging Neuroscience·Jeffery M ReddanAndrew Pipingas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.