Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea

Scientific Reports
Ji LiQing-Kun Song

Abstract

This meta-analysis aimed to investigate the protective effects of bovine colostrum against childhood infectious diarrhea. A systematic search was conducted using PubMed, Cochrane Library databases and clinicaltrial.gov. Among 166 research articles, only five RCTs were included into final analysis. Review manager (version 5.2) was used to pool the effect-size across studies. Sensitivity and risk of bias were estimated accordingly. Under a pooled analysis, bovine colostrum consumption correlated with a significant reduction in stool frequency of infectious diarrhea, by 1.42 times per day (95% CI: -2.70, -0.14). Bovine colostrum intervention also reduced occurrence of diarrhea by 71% (pooled OR = 0.29, 95%CI 0.16, 0.52). The OR of positive detection of pathogen in the stool was 0.29 (95%CI 0.08, 0.71) in bovine colostrum treated group, compared with placebo group. In the sensitivity analysis of studies with low risk of biases, bovine colostrum significantly reduced stool frequency, occurrence of diarrhea and pathogen detection. BC and related products have a significant benefit in reducing the frequency and relieving the symptoms of childhood infectious diarrhea.

References

Jan 7, 1999·The Pediatric Infectious Disease Journal·S A SarkerL Hammerström
Jul 4, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Haifa Ibrahim TawfeekShalan Al-Mashikhi
Jul 20, 2010·Journal of Pediatric Gastroenterology and Nutrition·Yunes PanahiMohammad Mehdi Naghizadeh
Dec 22, 2010·The Pediatric Infectious Disease Journal·Penelope H Dennehy
Aug 2, 2011·The Clinical Respiratory Journal·Türkan Patıroğlu, Meda Kondolot
Oct 11, 2011·Appetite·Deniz Atalayer, Neil E Rowland
Jul 11, 2018·Frontiers in Nutrition·Laurien H UlfmanR J Joost van Neerven
Jul 15, 2018·BMC Gastroenterology·Pengwei CuiZhao-Jun Duan
Aug 24, 2018·PloS One·Iulia Elena FilipescuGabriele Brecchia

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Citations

Dec 12, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Xiaoyan GaoDuc Ninh Nguyen
Jul 3, 2021·Nutrients·Kanta Chandwe, Paul Kelly
Aug 28, 2021·Nutrients·Per Torp SangildDouglas G Burrin

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