PMID: 8947595Nov 1, 1996Paper

Bovine gamma/delta TcR+ T lymphocytes are stimulated to proliferate by autologous Theileria annulata-infected cells in the presence of interleukin-2

Scandinavian Journal of Immunology
R A CollinsC J Howard

Abstract

An in vitro model system has been developed in which freshly isolated resting WC1+ gamma/delta TcR+ T cells proliferate in response to cells transformed by the protozoan parasite Theileria annulata, providing a strategy in which the basis of activation of naive gamma/delta T cells can be investigated. Irradiated parasite-transformed cells stimulate the proliferation, but not cytolytic activity, of autologous peripheral blood mononuclear cells (PBMC) from non-immune animals. The proliferating cells are mainly WC1+ gamma/delta T cells. The majority of WC1+ gamma/delta T cells in freshly isolated PBMC express CD25 at a low level that increases when stimulated with T. annulata-infected cells. Purified WC1+ gamma/delta T cells fail to proliferate when cultured with irradiated T. annulata-infected cells and produce a small proliferative response to IL-2, but proliferate strongly to irradiated or lightly fixed Theileria-infected cells in combination with IL-2. The Theileria-infected cells express cytokine transcripts encoding IL-1 alpha, IL-1 beta, IL-6 and IL-10, but not IFN gamma, IL-2, IL-4 and IL-7. Purified WC1+ gamma/delta T cells stimulated with T. annulata-infected cells with or without IL-2 fail to produce IL-2 transcripts, b...Continue Reading

Citations

Mar 6, 2008·Tropical Animal Health and Production·M Al-DubaibM E Hashad
Aug 11, 2001·Veterinary Immunology and Immunopathology·P Sopp, C J Howard
Oct 18, 2002·Veterinary Immunology and Immunopathology·J M Pollock, M D Welsh
Dec 3, 2002·Veterinary Immunology and Immunopathology·T SathiyaseelanCynthia L Baldwin
Aug 7, 1998·Journal of Virological Methods·W NiedbalskiO Marquardt
Nov 5, 2002·Veterinary Microbiology·John H Wyckoff
May 8, 1999·Immunology·D M HaigH R Miller
Nov 7, 2001·Scandinavian Journal of Immunology·G AltreutherD Werling
Mar 19, 2014·Veterinary Immunology and Immunopathology·Jodi L McGillW Ray Waters
Jun 8, 2011·Veterinary Medicine International·Brandon L Plattner, Jesse M Hostetter
Feb 27, 1998·The Veterinary Quarterly·F H Borgsteede, G van Beek
Feb 11, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Hiromichi OhtsukaYousuke Maeda
Oct 24, 2003·Cellular Immunology·Raquel Hontecillas, Josep Bassaganya-Riera
Nov 5, 1999·Annual Review of Microbiology·D Dobbelaere, V Heussler
Jun 17, 2010·BMC Evolutionary Biology·Carolyn T A HerzigJanice C Telfer
Dec 29, 2007·Immunological Investigations·W R Waters, R E Sacco
Feb 16, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ming Y DengThomas S McKenna
Jan 20, 2007·Journal of Leukocyte Biology·Ildiko Van RhijnAd P Koets
Apr 13, 2007·European Journal of Immunology·Seth L BlumermanCynthia L Baldwin
Dec 24, 1997·Environmental Health Perspectives·M C Jaurand
Feb 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodi L McGillW Ray Waters

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