journal cover

Bovine herpesvirus tegument protein VP22 enhances thymidine kinase/ganciclovir suicide gene therapy for neuroblastomas compared to herpes simplex virus VP22

Journal of Virology

Mar 30, 2004

Zhaohua QiuG A Splitter

Abstract

Herpesvirus tegument protein VP22 can enhance the effect of therapeutic proteins in gene therapy, such as thymidine kinase (tk) and p53; however, the mechanism is unclear or controversial. In this study, mammalian expression vectors carrying bovine herpesvirus 1 (BHV-1) VP22 (BVP22) or ...read more

Mentioned in this Paper

Thymidine Kinase
Study
In Vivo
VP(1)
Shuttle Vectors
Transfection
Cytotoxicity Assay
Bmx protein, mouse
Therapeutic protein
expression vector
Paper Details
References
  • References28
  • Citations13
123
  • References28
  • Citations13
12

Similar Papers Found In These Feeds

Herpes Simplex Infections

Herpes simplex virus infections are one of the most common sexually transmitted diseases and are classified as either type 1 (cold sores) or type 2 (genital herpes). Discover the latest research on Herpes Simplex Virus here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Neuroblastoma in Zebrafish

This feed focuses on neuroblastoma in Zebrafish, as well as MYCN and ALK oncogenes which are highly expressed in neuroblastoma. Here is the latest research.

Vectors in Gene Therapy

The delivery of genes into DNA for gene therapy is done through the use of vectors, which are often viral vectors. These vectors can be manipulated to include DNA and RNA depending on the type of therapy that is needed. Here is the latest research on vector gene therapy.

Gene Therapy

The use of DNA as a technique for treating disease is a key feature of gene therapy. This type of treatment is being investigated to either replacement of a mutated gene with a healthy copy, silence a mutated gene that is dysfunctional or insert a novel gene to help fight disease. Discover the latest research on gene therapy here.

Related Papers

© 2020 Meta ULC. All rights reserved

Bovine herpesvirus tegument protein VP22 enhances thymidine kinase/ganciclovir suicide gene therapy for neuroblastomas compared to herpes simplex virus VP22

Journal of Virology

Mar 30, 2004

Zhaohua QiuG A Splitter

PMID: 15047837

DOI: 10.1128/jvi.78.8.4224-4233.2004

Abstract

Herpesvirus tegument protein VP22 can enhance the effect of therapeutic proteins in gene therapy, such as thymidine kinase (tk) and p53; however, the mechanism is unclear or controversial. In this study, mammalian expression vectors carrying bovine herpesvirus 1 (BHV-1) VP22 (BVP22) or ...read more

Mentioned in this Paper

Thymidine Kinase
Study
In Vivo
VP(1)
Shuttle Vectors
Transfection
Cytotoxicity Assay
Bmx protein, mouse
Therapeutic protein
expression vector

Similar Papers Found In These Feeds

Herpes Simplex Infections

Herpes simplex virus infections are one of the most common sexually transmitted diseases and are classified as either type 1 (cold sores) or type 2 (genital herpes). Discover the latest research on Herpes Simplex Virus here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy

Proceedings of the National Academy of Sciences of the United States of AmericaAugust 18, 1999
L D StegmanB D Ross
Paper Details
References
  • References28
  • Citations13
123
  • References28
  • Citations13
12
/papers/bovine-herpesvirus-tegument-protein-vp22-enhances/15047837