PMID: 2492006Jan 1, 1989Paper

Bovine islets of Langerhans. Potential source for transplantation?

Diabetes
B J HeringK F Federlin

Abstract

Two methods are described for large-scale isolation of islets from the bovine pancreas. With the single-endpoint technique the average number of islets isolated from a 73.3-g pancreas sample was 150,560, representing an estimated total islet volume of 0.391 ml. Pancreases processed by the continuous digestion-filtration method yielded an average of 246,229 islets from a 93.9-g pancreas sample, representing an estimated total islet volume of 0.458 ml. Isolated bovine pancreatic islets demonstrated a well-preserved endocrine cell ultrastructure, responded to acute stimulation with propionic acid, and temporarily reversed experimental diabetes in mice.

Citations

Sep 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·L A Kirsanova, V N Bliumkin
Apr 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·L A KirsanovaV V Severin
Jul 1, 1990·Acta diabetologica latina·C RicordiR Alejandro
Jan 12, 1999·Diabetes Research and Clinical Practice·H OhgawaraS Miyazaki
Feb 1, 1990·Metabolism: Clinical and Experimental·R CalafioreP Brunetti

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