PMID: 8938844Nov 1, 1996Paper

Bovine leucocyte adhesion deficiency: a review of a modern disease and its implications

Research in Veterinary Science
A S Gerardi

Abstract

Bovine leucocyte adhesion deficiency (BLAD) is a genetic disease of cattle which affects the hematopoietic system. In the last decade BLAD has become a disease of economic importance in the dairy industry. This review describes the chronological developments and thinking that led to the elucidation of BLAD as a disease distinct from previous models in canine and human populations. All species affected show signs of chronic and recurrent infections. Necrotic and/or gangrenous infections of soft tissues are prevalent, in addition to secondary infections with bacteria or fungi. Low birthweight and unthriftiness are key signs in all species affected by leucocyte adhesion deficiency (LAD). Dermatomycoses and impaired pus formation are also common findings. The physiological basis for BLAD is a deficiency in the chemotactic and phagocytic properties of leucocytes and particularly neutrophils. The inhibition of diapedesis in the inflammatory response prevents normal immune reactions to invading pathogens. Chronic infections are a consequence of the faulty immune mechanisms. The biochemical aetiology of BLAD involves cell surface glycoprotein molecules known as integrins. These are responsible for the cell-cell interactions necessary f...Continue Reading

References

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Citations

Dec 25, 2002·Theriogenology·C GalliG Lazzari
Jul 18, 2006·Acta Veterinaria Hungarica·B Akyüz, O Ertuğrul
Jan 9, 2001·The Veterinary Journal·B L CoomberP A Gentry
Aug 15, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Leonie RolandMichael Iwersen
Mar 18, 2008·Journal of Animal Science·T B FarranJ S Drouillard
Sep 5, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·J P ShannonR S Larson

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