Bovine leukemia virus DNA associated with breast cancer in women from South Brazil

Scientific Reports
Daniela SchwingelLuiz C Kreutz

Abstract

Breast cancer is a neoplastic condition with a high morbidity and mortality amongst women worldwide. Recent data linking bovine leukemia virus (BLV) with breast cancer has been contested already. Our study investigated the presence of BLV genome in healthy (n = 72) and cancerous (n = 72) paraffin-embedded samples of breast tissues from women in south Brazil. BLV DNA was found most frequently (30.5%) in breast cancer tissue than in healthy breast (13.9%) (Odds ratio = 2.73; confidence interval = 1.18-6.29; p = 0.027). In contrast, antibodies to BLV were found in a very small percentage of healthy blood donors. There was no association between BLV DNA and other tumor prognostic biological markers such as hormonal receptors, HER2 oncoprotein, proliferation index, metastasis in sentinels lymph nodes, and tumor grade and size. Our findings suggest that BLV should be considered a potential predisposing factor to breast cancer in women.

References

Dec 1, 1981·Veterinary Research Communications·M J Burridge
Aug 1, 1996·Journal of Virology·R A Reyes, G L Cockerell
Nov 6, 2003·Cancer·James S MichaelsonBarbara Smith
Jan 8, 2004·AIDS Research and Human Retroviruses·Gertrude Case BuehringK Yeon Choi
Jul 29, 2005·Clinical and Laboratory Haematology·S KamihiraY Yamada
Aug 18, 2009·Breast Cancer Research and Treatment·Christopher M HeaphyMarco Bisoffi
Nov 26, 2010·Nature Reviews. Cancer·Patrick S Moore, Yuan Chang
Jan 18, 2011·Virus Research·Hironobu MurakamiHiroshi Sentsui
Apr 13, 2013·International Journal of Cancer. Journal International Du Cancer·Brian Salmons, Walter H Gunzburg
Apr 5, 2014·Journal of the American Veterinary Medical Association·Paul C BartlettRonald J Erskine
Apr 23, 2014·Emerging Infectious Diseases·Gertrude Case BuehringGerard Nuovo
Dec 17, 2014·Annals of Global Health·Jin-Kyoung Oh, Elisabete Weiderpass
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 20, 2016·Breast Cancer Research : BCR·Isabell WitzelHarriet Wikman
Jul 15, 2016·British Journal of Cancer·Lary A RobinsonScott Antonia
Aug 1, 2016·Archives of Virology·Ramiro MerliniKarina Trono
Apr 7, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Fernando V BauermannDavid A Dargatz
Jun 6, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ana Paula AndreollaLuiz Carlos Kreutz

❮ Previous
Next ❯

Citations

Apr 8, 2020·Journal of Occupational and Environmental Hygiene·Agata Stobnicka-KupiecMarcin Cyprowski
Jan 2, 2020·International Journal of Environmental Research and Public Health·Gertrude C Buehring, Hannah M Sans
Oct 6, 2020·PloS One·Emília DelarmelinaJenner Karlisson Pimenta Dos Reis
Jul 31, 2020·Microbial Pathogenesis·Andrew GaoIgor F Tsigelny
Jun 11, 2021·Infectious Agents and Cancer·James S Lawson, Wendy K Glenn
Sep 8, 2021·MBio·Joshua A Hayward, Gilda Tachedjian

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR
electrophoresis

Software Mentioned

GelReady®
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.