Bovine leukemia virus-gp51 antigen expression is associated with CD5 and IgM markers on infected lymphocytes

Veterinary Immunology and Immunopathology
R MeiromJ Brenner

Abstract

Cows that develop a persistent lymphocytosis (PL) as a result of bovine leukemia virus (BLV) infection develop massive proliferation of B-lymphocytes expressing both IgM and CD5 markers. The association of these two markers on peripheral blood mononuclear cells (PBMC) derived from BLV-infected cows and also expressing BLV-gp51 antigen marker on these cells was determined by three-color cytometric analysis. After in vitro cultivation of PBMC in the presence of PHA for 24 h, the mean percentages of marker-reactive cells of five PL+ cows were as follows; 43% +/- 4.5 of the PBMC expressed BLV-gp51 antigen; 90% +/- 1.6 of these cells expressed both IgM and CD5 at the same time, whereas but 7.5% +/- 1.9 expressed only IgM and 2.9% +/- 0.4 expressed only CD5. The PBMC, IgM positive cells accounted for 77.8% +/- 6.8, while both CD5 and BLV-gp51 were detected simultaneously on 52.0% +/- 2.4 of the IgM+ cells, while the CD5 marker and BLV-gp51 antigen were detected independently on 35.0% +/- 1.9 and in 9.0% +/- 3.1, respectively of the IgM+ cells. Of the CD5+ cells (equivalent to 75.5% +/- 9.0 of the PBMC), 54.7% +/- 4.7 expressed simultaneously IgM and BLV-gp51, while BLV-gp51 and IgM were expressed separately by 3.0% +/- 0.5 and 37.8% ...Continue Reading

References

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Citations

Feb 6, 2010·Retrovirology·Prabal BanerjeeGerold Feuer
Jan 3, 2015·Veterinary Immunology and Immunopathology·Meredith C Frie, Paul M Coussens
Jun 22, 2018·PloS One·Adriana Patricia CorredorMaría Fernanda Gutiérrez
Nov 10, 2018·Frontiers in Veterinary Science·Vanesa RuizIrene Alvarez

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