PMID: 9557733Apr 29, 1998Paper

Bovine leukemia virus-induced lymphocytosis and increased cell survival mainly involve the CD11b+ B-lymphocyte subset in sheep

Journal of Virology
N ChevallierIsabelle Schwartz-Cornil

Abstract

In this study, we show that bovine leukemia virus (BLV)-induced persistent lymphocytosis (PL) results from the in vivo expansion of the CD11b+ B-lymphocyte population. This subset shares phenotypic characteristics with murine and human B-1 cells. BLV interactions with the sheep B-1-like subset were explored. We found that B-1- and B-2-like cells are initially infected to similar extents. However, in long-term-infected sheep, the viral load is higher in B-1-like cells and only B-1- and not B-2-like cells show increased ex vivo survival compared to that in uninfected sheep. Ex vivo viral expression was found in both B-1- and B-2-like cells, indicating that both cell types support viral replication. Finally, cycloheximide and a protein kinase C inhibitor (H7) that blocks the ex vivo activation of viral expression did not affect the increased survival in B-1-like cells, suggesting that resistance to apoptosis is acquired in vivo. Collectively, these results indicate a peculiar susceptibility of sheep B-1-like cells to BLV transforming effects and further support the involvement of increased survival in BLV pathogenesis.

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Citations

Nov 18, 2000·AIDS Research and Human Retroviruses·L WillemsR Kettmann
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florentina PascaleIsabelle Schwartz-Cornil
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christophe DebacqLuc Willems
Nov 21, 1998·Immunology·N ChevallierI Schwartz-Cornil
Dec 7, 2005·Journal of Leukocyte Biology·Michel BonneauIsabelle Schwartz-Cornil
Nov 7, 2001·Scandinavian Journal of Immunology·G AltreutherD Werling
Dec 17, 2005·American Journal of Respiratory and Critical Care Medicine·Jean François CailhierJeremy Hughes
Aug 11, 2001·Veterinary Immunology and Immunopathology·H KabeyaM Onuma
Jan 3, 2015·Veterinary Immunology and Immunopathology·Meredith C Frie, Paul M Coussens

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis