Bovine Nebovirus Interacts with a Wide Spectrum of Histo-Blood Group Antigens

Journal of Virology
Eun-Hyo ChoKyoung-Oh Cho

Abstract

Some viruses within the Caliciviridae family initiate their replication cycle by attachment to cell surface carbohydrate moieties, histo-blood group antigens (HBGAs), and/or terminal sialic acids (SAs). Although bovine nebovirus (BNeV), one of the enteric caliciviruses, is an important causative agent of acute gastroenteritis in cattle, its attachment factors and possibly other cellular receptors remain unknown. Using a comprehensive series of protein-ligand biochemical assays, we sought to determine whether BNeV recognizes cell surface HBGAs and/or SAs as attachment factors. It was found that BNeV virus-like particles (VLPs) bound to A type/H type 2/Ley HBGAs expressed in the bovine digestive tract and are related to HBGAs expressed in humans and other host species, suggesting a wide spectrum of HBGA recognition by BNeV. BNeV VLPs also bound to a large variety of different bovine and human saliva samples of all ABH and Lewis types, supporting previously obtained results and suggesting a zoonotic potential of BNeV transmission. Removal of α1,2-linked fucose and α1,3/4-linked fucose epitopes of target HBGAs by confirmation-specific enzymes reduced the binding of BNeV VLPs to synthetic HBGAs, bovine and human saliva, cultured cel...Continue Reading

References

Apr 8, 1985·Journal of Immunological Methods·M P WoodwardR A Bloodgood
Aug 4, 1998·Archives of Virology·M SugiedaS Nakajima
Feb 19, 2000·Biochemical and Biophysical Research Communications·C J Thomas, A Surolia
Mar 4, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·V Ravn, E Dabelsteen
May 17, 2000·The Journal of General Virology·J Schneider-Schaulies
Nov 23, 2000·Journal of Virology·N Ruvoën-ClouetJ Le Pendu
Aug 2, 2003·Current Opinion in Cell Biology·Lucas Pelkmans, Ari Helenius
Mar 22, 2005·Journal of Medical Virology·Marc-Alain WiddowsonMarion P Koopmans
Jul 16, 2005·Annals of Medicine·Sigvard Olofsson, Tomas Bergström
Feb 21, 2006·Emerging Infectious Diseases·Qiu-Hong WangLinda J Saif
Apr 14, 2006·Journal of Virology·Akiko MakinoHiroomi Akashi
Oct 17, 2006·Journal of Virology·Sonia CheethamLinda J Saif
Dec 16, 2006·The Journal of General Virology·Amanda D Stuart, T David K Brown
Dec 21, 2006·Archives of Virology·G ReuterG Szucs
Sep 7, 2007·Journal of Virology·Susan HafensteinMichael G Rossmann
Oct 24, 2007·Emerging Infectious Diseases·Kirsten MattisonJeffrey M Farber
Dec 26, 2008·Nature Chemical Biology·Thomas HaselhorstMark von Itzstein
Mar 14, 2009·Archives of Virology·Yvan L'HommeCarole Simard
May 5, 2009·Virology·Tilo SengerMartin Müller
Sep 24, 2009·Veterinary Microbiology·Barbara Regina Bank-WolfHeinz-Jürgen Thiel
Oct 9, 2009·Archives of Virology·Hyun-ok KeumBong-kyun Park
Dec 22, 2009·ACS Chemical Biology·Xi Chen, Ajit Varki
Sep 25, 2010·PLoS Pathogens·Ming Tan, Xi Jiang
Nov 16, 2010·Virology Journal·J Michael DayLaszlo Zsak
Mar 16, 2011·Archives of Virology·Sandro WolfPeter Otto
Jun 15, 2011·Veterinary Microbiology·Barbara Di MartinoFulvio Marsilio
Jul 14, 2011·Emerging Infectious Diseases·Jerome KaplonKatia Ambert-Balay

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Datasets Mentioned

BETA
EF528565
MG009451
MG009451.1

Methods Mentioned

BETA
electron microscopy
confocal microscopy
glycosylation
PCR
protein assay

Software Mentioned

EZ
HuNoVs
Adobe Photoshop
C1
GraphPad
Prism
GraphPad Prism

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