Bovine papillomavirus DNA in neoplastic and nonneoplastic tissues obtained from horses with and without sarcoids in the western United States

American Journal of Veterinary Research
E A CarrM E Hitchcock

Abstract

To determine the incidence of bovine papillomavirus (BPV) type 1 or 2 in sarcoids and other samples of cutaneous tissues collected from horses in the western United States. 55 horses with sarcoids and 12 horses without sarcoids. Tissue samples (tumor and normal skin from horses with sarcoids and normal skin, papillomas, and nonsarcoid cutaneous neoplasms from horses without sarcoids) were collected. Tissue samples were analyzed for BPV-1 or -2 DNA, using a polymerase chain reaction (PCR) and restriction fragment length polymorphism. The PCR products from 7 sarcoid-affected horses were sequenced to evaluate percentage homology with expected sequences for BPV-1 or-2. Most (94/96, 98%) sarcoids contained BPV DNA. Sixty-two percent of the tumors examined had restriction enzyme patterns consistent with BPV-2. Thirty-one of 49 (63%) samples of normal skin obtained from horses with sarcoids contained BPV DNA. All samples subsequently sequenced had 100% homology with the expected sequences for the specific viral type. All tissues from healthy horses, nonsarcoid neoplasms, and papillomas were negative for BPV DNA. Bovine papillomaviral DNA was detected in essentially all sarcoids examined. There appears to be regional variation in the p...Continue Reading

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Citations

Sep 11, 2013·Veterinary Microbiology·Lubna Nasir, Sabine Brandt
May 3, 2013·Journal of Clinical Microbiology·Michele LunardiAmauri Alcindo Alfieri
Jan 11, 2013·Infectious Agents and Cancer·Annunziata CorteggioGiuseppe Borzacchiello
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