Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte cultures

Parasite Immunology
W L GoffW C Brown

Abstract

The spleen is a critical effector organ functioning, in haemoparasitic diseases like babesiosis, to destroy the pathogen and clear the host of infected erythrocytes. It has an important role in both innate responses and adaptive immune responses. Young calves demonstrate a strong spleen-dependent innate response to an initial infection with Babesia bovis involving the type-1 regulating cytokines IL-12 and IFN-gamma. However, the specific splenic cell types that produce IFN-gamma in response to infection and the cellular factors that regulate the induction have not been fully determined. Splenic NKp46(+) NK cells were identified and purified. They consisted of CD3(-), CD2(+/-), and CD8(+/-) populations. NK cells responded to exogenous IL-12 and IL-18 with the production of IFN-gamma. Functionally, IL-18 served as a potent co-stimulant with IL-12 for IFN-gamma production. Finally, innate IFN-gamma production was induced in splenic NK cells in the presence of supernatants from B. bovis merozoite-exposed monocytes in an IL-12 pathway-dependent manner.

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Citations

Feb 25, 2011·Veterinary Research·Timothy ConnelleyIvan W Morrison
Feb 16, 2012·Parasites & Vectors·Danett K Brake, Adalberto A Pérez de León
Jul 30, 2014·Parasitology·Monica Florin-ChristensenLeonhard Schnittger
Feb 2, 2013·Immunopharmacology and Immunotoxicology·Tomasz Maślanka
Apr 3, 2009·Veterinary Immunology and Immunopathology·Preben Boysen, Anne K Storset
Jul 18, 2006·Parasite Immunology·W C BrownT F McElwain
Mar 3, 2006·Veterinary Parasitology·Wendy C BrownWill L Goff
Oct 2, 2012·Veterinary Immunology and Immunopathology·Hege LundAnne K Storset
Sep 18, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Anja SipkaYnte Schukken
Nov 11, 2015·Veterinary Immunology and Immunopathology·Sudhanshu Shekhar, Xi Yang
May 8, 2019·Parasite Immunology·Andrew LeisewitzJohan P Schoeman
Dec 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle N KellyJudd E Shellito
Mar 19, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy K ConnelleyW Ivan Morrison
Mar 16, 2019·Frontiers in Immunology·Daria L IvanovaJason P Gigley
Aug 6, 2020·International Journal of Molecular Sciences·Alessandra TorinaGuido Sireci
Oct 6, 2020·Frontiers in Immunology·Ligia CavaniHenrique Nunes de Oliveira
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Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Teresia W MainaJodi L McGill
Jul 31, 2016·Research in Veterinary Science·Tomasz MaślankaJerzy J Jaroszewski

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