Bovine spongiform encephalopathy agent in spleen from an ARR/ARR orally exposed sheep

The Journal of General Virology
Olivier AndréolettiF Lantier

Abstract

Oral contamination with bovine spongiform encephalopathy (BSE) agent in susceptible PRNP genotype sheep results in widespread distribution of prion in the host. Because ARR homozygous sheep are considered to be resistant to transmissible spongiform encephalopathies, they have been selected to eradicate scrapie from sheep flocks and to protect the human food chain from small ruminant BSE risk. However, results presented here show that several months after an oral challenge with BSE agent, healthy ARR/ARR sheep can accumulate significant amounts of PrP(Sc) in the spleen.

References

Jan 7, 2000·The American Journal of Pathology·W J Schulz-SchaefferH A Kretzschmar
Oct 5, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Olivier AndréolettiFrançois Schelcher
May 30, 2003·Nature·Fiona HoustonNora Hunter
Jun 10, 2003·Revue Scientifique Et Technique·L A Detwiler, M Baylis
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter AichelePeter Seiler
May 25, 2004·Nature Medicine·O AndréolettiF Schelcher
Apr 19, 2005·The Veterinary Record·Marc EloitPierre Sarradin

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Citations

Apr 7, 2007·Proceedings. Biological Sciences·Helen R FryerAngela R McLean
Feb 18, 2011·Veterinary Research·Martin EidenMartin H Groschup
Oct 13, 2009·BMC Veterinary Research·Glenda DexterDanny Matthews
Oct 24, 2007·Emerging Infectious Diseases·Martin H GroschupOlivier Andreoletti
Feb 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Pierre SarradinJean-Luc Gatti
Jan 9, 2016·Veterinary Research·Carlos HedmanJuan José Badiola
Oct 9, 2007·Journal of Neurochemistry·Domenico PaludiTullio Florio
Oct 20, 2006·Biochemical and Biophysical Research Communications·Frédéric RonzonThierry Baron
Jul 10, 2009·The Journal of General Virology·G C SaundersF Lantier
Jan 8, 2008·The Journal of Veterinary Medical Science·Jiro OharaMotohiro Horiuchi
Sep 13, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Paul R WebbYvonne I Spencer
Nov 23, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Torsten SeuberlichAndreas Zurbriggen
Nov 29, 2013·Journal of Virology·Caroline LacrouxOlivier Andréoletti
Sep 21, 2019·Annual Review of Genetics·Simon MeadJohn Collinge
Mar 22, 2007·The Journal of General Virology·Juan Carlos EspinosaJuan María Torres

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