Bovine telomere dynamics and the association between telomere length and productive lifespan

Scientific Reports
Luise A SeekerGeorgios Banos

Abstract

Average telomere length (TL) in blood cells has been shown to decline with age in a range of vertebrate species, and there is evidence that TL is a heritable trait associated with late-life health and mortality in humans. In non-human mammals, few studies to date have examined lifelong telomere dynamics and no study has estimated the heritability of TL, despite these being important steps towards assessing the potential of TL as a biomarker of productive lifespan and health in livestock species. Here we measured relative leukocyte TL (RLTL) in 1,328 samples from 308 Holstein Friesian dairy cows and in 284 samples from 38 female calves. We found that RLTL declines after birth but remains relatively stable in adult life. We also calculated the first heritability estimates of RLTL in a livestock species which were 0.38 (SE = 0.03) and 0.32 (SE = 0.08) for the cow and the calf dataset, respectively. RLTL measured at the ages of one and five years were positively correlated with productive lifespan (p < 0.05). We conclude that bovine RLTL is a heritable trait, and its association with productive lifespan may be used in breeding programmes aiming to enhance cow longevity.

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Citations

May 4, 2020·GeroScience·Jessica M Hoffman, Teresa G Valencak
Nov 22, 2019·Frontiers in Genetics·Joanna J Ilska-WarnerGeorgios Banos
Oct 14, 2020·Molecular Ecology Resources·Megan L PowerEmma C Teeling
Nov 5, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jean-François LemaîtreEmmanuelle Gilot-Fromont
Feb 16, 2021·Molecular Ecology·Alexandra M SparksHannah L Dugdale
Apr 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Hannah FroyDaniel H Nussey
Aug 21, 2021·Frontiers in Genetics·Honghong HuYun Ma
Nov 27, 2021·Molecular Ecology·Michael Le PepkeThor Harald Ringsby
Aug 27, 2021·Molecular Ecology·Florentin RemotJean-François Lemaitre
Dec 6, 2021·Molecular Ecology·Michael ToblerDennis Hasselquist

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

LinReg PCR
Primerdesign
ASReml
lme4
R
NanoDrop
qbase +

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