PMID: 6409499May 1, 1983Paper

Bovine tracheal cartilage proteoglycans. Variations in structure and composition with age

Collagen and Related Research
S Inerot, D Heinegård

Abstract

The variation with age in structure and composition of proteoglycans from bovine tracheal cartilage was studied from fetal life to 12 years of age. Cartilage content of proteoglycans as related to collagen was found to increase with age. The extractability of the proteoglycans decreases markedly with age. Extracted proteoglycans were characterized and change during growth and maturation as follows: 1. They contain fewer chondroitin sulfate chains. The chains are of constant size; but at higher ages they are more highly sulfated, primarily with 6-sulfate groups. 2. They contain an increasing number of constant size keratan sulfate chains, while the number of O-linked oligosaccharides (structurally related to the keratan sulfate linkage region to protein) decreases. 3. They become smaller, at least partially, as a result of an increasing proportion of a smaller size proteoglycan. 4. They have a higher protein content. The changes can largely be attributed to an early shift (up to 22 months of age) from a predominating large chondroitin sulfate rich proteoglycan in the youngest cartilage to increasing proportions of a distinct, smaller keratan sulfate rich proteoglycan. During subsequent aging all molecular parameters as well as p...Continue Reading

References

Jan 30, 1975·Biochimica Et Biophysica Acta·W StriderL Rosenberg
Apr 1, 1978·Annals of the Rheumatic Diseases·M F Venn
Aug 1, 1979·Annals of the Rheumatic Diseases·R J Elliott, D L Gardner
Jul 1, 1966·The Journal of Clinical Investigation·M B Mathews, S Glagov
Sep 15, 1972·Biochimica Et Biophysica Acta·T E Hardingham, H Muir
Aug 29, 1967·Biochimica Et Biophysica Acta·R D Campo, C D Tourtellotte
Nov 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·H Stegemann, K Stalder
Feb 1, 1981·Archives of Biochemistry and Biophysics·T R Oegema, F Behrens
Aug 1, 1981·The Biochemical Journal·D HeinegårdC Carlström
May 1, 1981·Archives of Biochemistry and Biophysics·E J Thonar, M B Sweet
Dec 1, 1980·Hoppe-Seyler's Zeitschrift für physiologische Chemie·G F TriphausE Buddecke
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR

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Citations

Mar 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·J P BinetteK Schmid
Dec 1, 1985·Collagen and Related Research·J E Scott
Nov 1, 1985·Collagen and Related Research·R KuijerJ K van der Korst
Mar 1, 1985·Collagen and Related Research·B WikströmA Hjerpe
Dec 1, 1987·Collagen and Related Research·S Inerot, D Heinegård
Jan 1, 1988·Connective Tissue Research·R KuijerJ K van der Korst
Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S InerotL Audell
Dec 5, 2009·International Journal of Experimental Pathology·Dick Heinegård
Nov 1, 1987·Archives of Biochemistry and Biophysics·K SugaharaI Yamashina
Aug 15, 1992·Archives of Biochemistry and Biophysics·C FlanneryJ Sandy
Aug 1, 1996·Archives of Oral Biology·T Nakano, P G Scott
Jan 1, 1984·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J R ZirnR L Smith
Jan 1, 1988·The American Journal of Anatomy·R Mallinger, L Stockinger
Nov 15, 1985·Analytical Biochemistry·D HeinegårdB Larsson
Jan 1, 1987·Connective Tissue Research·V Stanescu, F Chaminade
Jan 1, 1985·Connective Tissue Research·M B ContriI P Ronchetti
Jun 22, 2015·Micron : the International Research and Review Journal for Microscopy·Priscila Eliane dos Santos LaureanoMarcelo Augusto Marretto Esquisatto
Apr 1, 1992·Acta Odontologica Scandinavica·S AxelssonA Hjerpe
Mar 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A J DeutschA H Plaas
Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H R LeipoldG Lust
Nov 1, 1988·Journal of Neurochemistry·H G Jenkins, H S Bachelard
Nov 1, 1988·Journal of Neurochemistry·H G Jenkins, H S Bachelard
Mar 22, 1996·The Journal of Biological Chemistry·H KitagawaK Sugahara
Aug 1, 1993·Current Eye Research·S SawaguchiT Kaiya
Apr 27, 2000·The Journal of Biological Chemistry·H KitagawaK Sugahara

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