Bovine Tuberculosis in Cattle: Vaccines, DIVA Tests, and Host Biomarker Discovery

Annual Review of Animal Biosciences
H Martin VordermeierBernardo Villarreal-Ramos

Abstract

Bovine tuberculosis remains a major economic and animal welfare concern worldwide. Cattle vaccination is being considered as part of control strategies. This approach, used alongside conventional control policies, also requires the development of vaccine-compatible diagnostic assays to distinguish vaccinated from infected animals (DIVA). We discuss progress made on optimizing the only potentially available vaccine, bacille Calmette Guérin (BCG), and on strategies to improve BCG efficacy. We also describe recent advances in DIVA development based on the detection of host cellular immune responses by blood-testing or skin-testing approaches. Finally, to accelerate vaccine development, definition of host biomarkers that provide meaningful stage-gating criteria to select vaccine candidates for further testing is highly desirable. Some progress has also been made in this area of research, and we summarize studies that defined either markers predicting vaccine success or markers that correlate with disease stage or severity.

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Citations

Nov 20, 2016·Annual Review of Animal Biosciences·Michael J MyersPhillip G Turfle
Feb 9, 2017·Memórias do Instituto Oswaldo Cruz·Caroline RizziOdir Antônio Dellagostin
May 26, 2017·American Journal of Veterinary Research·Sylvia I WanzalaSrinand Sreevatsan
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May 23, 2018·The Journal of Dairy Research·Marco IannacconeRosanna Capparelli
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Nov 30, 2019·Scientific Reports·Aneesh ChandranJohnjoe McFadden
Sep 23, 2020·Microorganisms·Yashdeep PhanseAdel M Talaat
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Methods Mentioned

BETA
genetic modifications
RNASeq
ELISA

Software Mentioned

RNASeq
DIVA

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