Bovine tuberculosis vaccine research: historical perspectives and recent advances

Vaccine
W R WatersH Martin Vordermeier

Abstract

The emergence of wildlife reservoirs of Mycobacterium bovis infection in cattle as well as increased inter-regional trade with associated spread of M. bovis has led to renewed interest in the use of vaccines for the control of bovine tuberculosis (TB). Field efficacy trials performed in the early 20th century demonstrated the partial effectiveness of bacilli Calmette-Guerin (BCG) for the control of bovine TB. Recent experimental trials with cattle have demonstrated that: (1) subunit vaccines may boost immunity elicited by BCG in cattle, (2) T cell central memory immune responses evoked by protective vaccines correlate with protection upon subsequent M. bovis challenge, (3) BCG is particularly protective when administered to neonates, and (4) differentiation of infected from vaccinated animals (DIVA) is feasible in cattle using in vitro or in vivo methods. In regards to wildlife reservoirs, the efficacy of BCG delivered orally has been demonstrated for brushtail possums (in field trials) as well as Eurasian badgers, wild boar, and white-tailed deer (each in experimental challenge studies). Vaccine delivery to wildlife reservoirs will primarily be oral, although a parenteral route is being deployed for badgers in England. Vaccine...Continue Reading

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Citations

Mar 19, 2014·Veterinary Immunology and Immunopathology·Jodi L McGillW Ray Waters
Apr 1, 2014·The Journal of Veterinary Medical Science·Duanne Alves Da SilvaAndré Kipnis
Apr 16, 2014·Research in Veterinary Science·M DomingoA Marco
Aug 9, 2013·Proceedings. Biological Sciences·H Charles J GodfrayAngela R McLean
Feb 18, 2016·Annual Review of Animal Biosciences·H Martin VordermeierBernardo Villarreal-Ramos
Feb 26, 2016·Veterinary Immunology and Immunopathology·H Martin VordermeierR Glyn Hewinson
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Nov 6, 2013·Transboundary and Emerging Diseases·B M BuddleA Heiser
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Jan 8, 2014·Vaccine·Bhagwati KhatriH Martin Vordermeier
Apr 22, 2015·Tropical Animal Health and Production·Miguel MelladoJose Eduardo García
Jan 15, 2015·New Zealand Veterinary Journal·B Warburton, P Livingstone
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Christopher K Tuggle, W Ray Waters
Jun 16, 2012·Veterinary Immunology and Immunopathology·Ramon A Juste
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May 10, 2013·BMC Veterinary Research·Tyler C ThackerWade Ray Waters
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Feb 7, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Pere-Joan Cardona, Ann Williams
Feb 9, 2017·Memórias do Instituto Oswaldo Cruz·Caroline RizziOdir Antônio Dellagostin
Sep 14, 2017·Journal of Molecular Microbiology and Biotechnology·Federico Carlos BlancoFabiana Bigi
Mar 24, 2017·Clinical and Vaccine Immunology : CVI·Gareth J JonesH Martin Vordermeier
Dec 18, 2015·Clinical and Vaccine Immunology : CVI·W Ray WatersMichelle H Larsen

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