BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing

Current Pharmaceutical Design
Sven SeiwerthPredrag Sikiric

Abstract

Commonly, the angiogenic growth factors signify healing. However, gastrointestinal ulceration is still poorly understood particularly with respect to a general pharmacological/pathophysiological role of various angiogenic growth factors implemented in growth factors wound healing concept. Thereby, we focused on the stable gastric pentadecapeptide BPC 157, a peptide given always alone vs. standard peptidergic angiogenic growth factors (EGF, FGF, VEGF), and numerous carriers. Further, we reviewed how the gastrointestinal tract healing could be generally perceived (i) in terms of angiogenic growth factors, and/or (ii) through the healing of extragastrointestinal tissues healing, such as tendon, ligament, muscle and bone, and vice versa. Respected were the beneficial effects obtained with free peptides or peptides with different carriers; EGF, FGF, VEGF, and BPC 157, their presentation along with injuries, and a healing commonality, providing their implementation in both gastrointestinal ulcer healing and tendon, ligament, muscle and bone healing. Only BPC 157 was consistently effective in all of the models of acute/chronic injury of esophagus, stomach, duodenum and lower gastrointestinal tract, intraperitoneally, per-orally or loc...Continue Reading

Citations

Jan 25, 2020·Oxidative Medicine and Cellular Longevity·Sanja KonosicPredrag Sikiric
Jun 20, 2020·Brain and Behavior·Jakša VukojevićPredrag Sikirić
Apr 1, 2020·World Journal of Gastrointestinal Pathophysiology·Slaven GojkovicPredrag Sikiric
Dec 1, 2020·World Journal of Gastrointestinal Pharmacology and Therapeutics·Lidija Berkopic CesarPredrag Sikiric
Jun 29, 2021·Frontiers in Pharmacology·Mirna ZlatarPredrag Sikiric
Jul 17, 2021·Frontiers in Pharmacology·Sven SeiwerthPredrag Sikiric
Aug 13, 2021·Neural Regeneration Research·Jakša VukojevicPredrag Sikirić
Dec 31, 2021·Frontiers in Pharmacology·Marijan TepesPredrag Sikiric

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