Brachial plexus paralysis due to giant cavernous hemangioma with Kasabach-Merritt syndrome: successful management with interferon alpha

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Erdal PekerAhmet F Oner

Abstract

Giant hemangiomas are rare in newborn babies and may cause some life-threatening complications such as congestive heart failure and coagulopathies including severe thrombocytopenia, microangiopathic hemolytic anemia and bleeding such as Kasabach-Merritt syndrome. We have presented here one infant case with a right lower brachial plexus paralysis due to giant hemangioma treated successfully with interferon alpha and have discussed the treatment. This is the first case of Kasabach-Merritt syndrome associated with a right lower brachial plexus paralysis treated with interferon in the literature to our knowledge. The administration of interferon-alpha might be indicated as a therapy for severe, life-threatening and giant hemangiomas such as Kasabach-Merritt syndrome, especially when there is resistance to steroid. However, more extensive data and new patients are needed to clarify this issue.

References

May 28, 1992·The New England Journal of Medicine·R A EzekowitzJ Folkman
Sep 1, 1995·Journal of Child Neurology·J W LucasJ K Cure
Mar 20, 2001·The Journal of Clinical Investigation·D A Marchuk
May 16, 2002·European Journal of Pediatrics·Tanja FrevelErik Harms
Jul 29, 2008·Journal of Child Neurology·Ali H NaqviIsrael Alfonso

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Citations

Jun 13, 2014·BMC Pediatrics·Ping WangXiao-Wen Chen
Aug 30, 2016·Journal of Pediatric Hematology/oncology·Fredrick Dapaah-SiakwanTeresa Del Moral

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