Brachytherapy for Conservative Treatment of Invasive Penile Carcinoma: Prognostic Factors and Long-Term Analysis of Outcome

International Journal of Radiation Oncology, Biology, Physics
Alexandre EscandeCyrus Chargari

Abstract

To report the largest experience with brachytherapy as a conservative approach for the treatment of penile carcinoma. We examined the outcomes of 201 patients treated at our institution over 45 years for invasive squamous cell carcinoma of the glans penis by brachytherapy. With a median follow-up of 10.7 years, local relapse as first failure was reported in 37 patients (18.9%), and 24 of 31 patients (77.4%) with local failure only were in complete remission after new treatment. At last follow-up 25 patients (12.4%) underwent partial surgery and 7 (3.5%) total penectomies for relapse. Fifty patients (24.8%) presented urethral stenosis requiring at least 1 dilatation, and 14 (7%) required limited surgeries for toxicities. At 5 years the estimated overall survival rate was 79% (95% confidence interval 73%-85%). The estimated original local control rate was 82% (95% confidence interval 76%-88%). Presence of inguinal lymph node metastasis and tumor size correlated with a poorer overall and disease-free survival in univariate and multivariate analyses. In univariate analysis, neutrophilia at diagnosis correlated with a higher probability of distant relapse (P=.025), and a dose ≥62 Gy correlated with better local control in N0 patient...Continue Reading

Citations

Aug 25, 2017·Acta Oncologica·Antoine SchernbergEric Deutsch
Jul 31, 2019·CA: a Cancer Journal for Clinicians·Cyrus ChargariChristine Haie-Meder
Jun 29, 2018·Nature Reviews. Urology·Jonathan Tward
Oct 31, 2018·Deutsches Ärzteblatt International·Oliver Walther HakenbergChris Protzel
Feb 5, 2021·Clinical and Translational Radiation Oncology·Nicolas MartzJean-Michel Hannoun-Levi
Aug 18, 2020·Cancer Treatment Reviews·Florent PeyraudAlain Ravaud
Jun 25, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J M Hannoun-LéviD Peiffert
Jun 12, 2018·Practical Radiation Oncology·Shireen ParsaiJay Ciezki

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