Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution

Evolution & Development
Kohji HottaTakashi Gojobori

Abstract

In vertebrates, Brachyury, a T-box transcription factor gene, seems to have a dual role in the differentiation of axial midline mesoderm cells into notochord and gastrulation cell movements regulated by non-canonical Wnt/planar cell polarity (Wnt/PCP) signaling. To understand the function of Brachyury-downstream genes in chordate embryos, from a series of our survey on differential expression, including subtractive hybridization, dot-blot assays, EST sequences and the expression patterns in whole-mount in situ hybridization at embryonic stages, we developed a knowledge database called "CINOBI: CionaNotochord and Brachyury-downstream gene Index" to create comprehensive catalogues of Brachyury-downstream gene sets in Ciona intestinalis. Combining genome and large-scale cDNA data, we were able to characterize 450 non-redundant Brachyury-downstream genes: Twenty-four genes were newly annotated as notochord-expressed genes. Several genes are components of signaling pathways such as Wnt/PCP, Nf kappaB and TGF-beta signaling. We propose that Brachyury is linked to these pathways regulating the expression of each component, and such a regulatory mechanism might be conserved among chordates.

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Citations

Nov 21, 2008·Development·Shota ChibaWilliam C Smith
May 11, 2013·BioMed Research International·Yutaka NibuAnna Di Gregorio
Jul 9, 2014·Zoological Science·Kuni TagawaNori Satoh
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Oct 11, 2014·Genesis : the Journal of Genetics and Development·Noriyuki SatohJohn Gerhart
Nov 18, 2014·Genesis : the Journal of Genetics and Development·Delphine Dauga
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Sep 21, 2017·Development·Wendy M ReevesMichael T Veeman
Apr 4, 2009·Zoological Science·Nori Satoh

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