Brachyury oncogene is a prognostic factor in high-risk testicular germ cell tumors

Andrology
Filipe PintoR M Reis

Abstract

The T-box transcription factor Brachyury has been considered a cancer-specific marker and a novel oncotarget in solid tumors. Brachyury overexpression has been described in various cancers, being associated with epithelial-mesenchymal transition, metastasis, and poor prognosis. However, its clinical association with testicular germ cell tumor is unknown. We analyzed the expression of Brachyury by immunohistochemistry in a series of well-characterized testicular germ cell tumor samples and at transcript level by in silico analysis. Additionally, we aimed to investigate the clinical significance of Brachyury in testicular germ cell tumor. Brachyury cytoplasm immunostaining was present in 89.6% (86/96) of cases with nuclear staining observed in 24% (23/96) of testicular germ cell tumor. Bioinformatics microarray expression analysis of two independent cohorts of testicular germ cell tumors showed similar results with increased levels of Brachyury in testicular germ cell tumors and metastasis compared with normal testis. Clinically, Brachyury nuclear staining was statistically associated with lower event-free survival (p = 0.04) and overall survival (p = 0.01) in intermediate/high-risk testicular germ cell tumors. Univariate analysi...Continue Reading

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Citations

Jan 24, 2019·Cellular and Molecular Life Sciences : CMLS·Aalia BatoolYi-Xun Liu
Mar 11, 2020·The Journal of Pathology·Filipe PintoRui M Reis
Aug 14, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Filipe PintoRui Manuel Reis
Jul 18, 2021·Advances in Medical Sciences·Lucas Faria Abrahao-MachadoRui M Reis

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