PMID: 9527187Apr 4, 1998Paper

Bradycardia induced by intravascular versus direct stimulation of the vagus nerve

The Annals of Thoracic Surgery
G W ThompsonJ A Armour

Abstract

Electrical stimulation of the parasympathetic nervous system results in slowing of the heart. We sought to determine whether cardiac vagal efferent axons can be stimulated adequately to induce bradycardia without disturbing the integrity of the thorax. Cardiodepressor effects elicited by direct stimulation of a vagus nerve in anesthetized dogs and pigs were compared with those generated when the same nerve was stimulated indirectly through bipolar electrodes placed in the adjacent superior vena cava. The heart rate of dogs decreased by about 80% when electrical stimuli were delivered to the right thoracic vagus at the level of the thoracic outlet through bipolar electrodes placed either in the adjacent superior vena cava (intravascular method) or directly on the nerve (direct method). Maximal responses were achieved with 10-V, 5-ms, and 20-Hz stimuli. In anesthetized pigs, similar bradycardia occurred when the right cervical vagus or the right cranial thoracic vagus was stimulated either directly or indirectly through the intravascular method. Atrial dysrhythmias occurred when the stimulating electrodes were placed by either method within 1 cm of the right atrium in both animal models. Controlled bradycardia can be induced duri...Continue Reading

References

Sep 1, 1992·The Annals of Thoracic Surgery·D A Murphy, J A Armour
Apr 1, 1986·The Anatomical Record·J G PhillipsJ A Armour
Jun 1, 1985·Canadian Journal of Physiology and Pharmacology·D A MurphyJ A Armour
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Jun 1, 1971·The Anatomical Record·W C RandallO A Smith
Jun 1, 1997·The Annals of Thoracic Surgery·R G Matheny, C J Shaar

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Citations

Dec 10, 1999·Journal of the American College of Cardiology·P SchauerteR Lazzara
Jul 1, 2006·Neuromodulation : Journal of the International Neuromodulation Society·Hendrik P BuschmanPeter van der Kemp
Nov 26, 1999·Journal of Cardiovascular Electrophysiology·P N SchauerteR Lazzara
Nov 8, 2015·International Journal of Colorectal Disease·A M WolthuisG E Boeckxstaens
Apr 18, 2012·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·James R MinerThomas J Hoffmann
Jul 30, 2015·Canadian Journal of Physiology and Pharmacology·Yves JammesStéphane Delliaux
Apr 22, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N StakenborgG E Boeckxstaens
Mar 13, 2014·Journal of Neural Engineering·Benjamin A TeplitzkyMatthew D Johnson
Jun 20, 2020·Journal of Neural Engineering·Evan N NicolaiKip A Ludwig
Aug 10, 2018·Psychopharmacology·Lindsey J NobleChrista K McIntyre
Jul 10, 2020·Physiological Reports·Kathryn A Hasenstab-KenneySudarshan R Jadcherla
Oct 8, 2020·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Soundararajan Dilip Chand RajaRishi Mugesh Kanna
May 11, 2020·Brain Stimulation·Kevin P ChengKip A Ludwig

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