Bradycardia produced by pyridostigmine and physostigmine

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
R D SteinC Polosa

Abstract

The bradycardia produced by pyridostigmine and physostigmine in an animal model of acute cardiac denervation was examined according to its relation to cholinesterase inhibition and sensitivity to block by cholinergic receptor antagonists. Cats were anaesthetised, vagotomised and propranolol-treated. Heart rate was continuously recorded. Erythrocyte cholinesterase activity of arterial blood was measured using a radiometric technique. Nicotinic and muscarinic M1 receptors were blocked with hexamethonium and pirenzepine, respectively. M2 receptors were blocked with gallamine, pancuronium and AFDX-116. With pyridostigmine and physostigmine the dose-response relationship for the decrease in heart rate (ED50 1.05 +/- 0.25 and 0.198 +/- 0.03 mg.kg-1, respectively) was shifted to the right of that for the inhibition of cholinesterase activity (ED50 0.094 +/- 0.03 and 0.032 +/- 0.01 mg.kg-1, respectively). The decrease in cholinesterase activity reached a plateau at a cumulative dose of 0.56 +/- 0.08 and 0.32 +/- 0.08 mg.kg-1, respectively. In contrast, there did not appear to be a plateau in the bradycardic effect. The bradycardia produced by pyridostigmine and physostigmine was blocked by hexamethonium (ED50 10 +/- 1.3 and 15.3 +/- 2....Continue Reading

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Citations

Aug 16, 2001·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A C NóbregaJ P Ribeiro
Apr 12, 2005·Pharmacology, Biochemistry, and Behavior·Oscar U ScreminDonald J Jenden
Oct 4, 2006·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Wolfgang SingerPhillip A Low
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·W SingerP A Low
Jul 11, 2014·Journal of Voice : Official Journal of the Voice Foundation·David L Young, Lucinda A Halstead
Jul 28, 2007·Pharmacotherapy·Wayne T NicholsonChristopher J Jankowski
Jul 22, 2006·Journal of Applied Toxicology : JAT·Oscar U ScreminDonald J Jenden
Aug 23, 2007·Journal of Cardiovascular Electrophysiology·Anil GehiJonathan Langberg

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