PMID: 8951836Dec 1, 1996Paper

Bradykinesia and movement precision in Huntington's disease

Neuropsychologia
J G PhillipsJ A Bradshaw

Abstract

To determine whether bradykinesia in patients with Huntington's disease (HD) reflects impaired force production or an increased requirement for terminal visual guidance, 11 HD patients and matched controls performed drawing movements with varying precision requirements. Participants used an electronic pen upon a WACOM SD420 graphics tablet to join targets of either 10 or 20 mm diameter which were separated by a distance of 62.5 or 125 mm. While HD patients had slower movements, exhibiting more cycles of acceleration and deceleration, patients were not disproportionately affected by variations in target size or separation. Bradykinesia did not seem to be a product of impaired force production or increased reliance upon terminal visual guidance, since neither accelerative or decelerative phases were specifically affected by HD. However, movements of HD patients were of less consistent duration, implying variability associated with internal cues regulating movement.

References

Jan 1, 1979·Neurology·I Shoulson, S Fahn
Mar 1, 1992·Journal of Clinical and Experimental Neuropsychology·J L BradshawJ A Bradshaw
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jun 1, 1987·Brain : a Journal of Neurology·H HefterH J Freund
Jun 1, 1980·Brain : a Journal of Neurology·M Hallett, S Khoshbin
Jul 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·N GeorgiouJ A Bradshaw
Jan 1, 1994·Experimental Brain Research·K E MartinJ L Bradshaw
Jun 1, 1994·Journal of Neurology·J G PhillipsR Iansek
Sep 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·J G PhillipsJ A Bradshaw

❮ Previous
Next ❯

Citations

Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·J P van VugtR A Roos
Jan 19, 2013·Experimental Brain Research·Sarah M Kranick, Mark Hallett
Jan 4, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M SchwarzJ Noth
Feb 22, 2000·Clinical Neuropharmacology·P J Garcia RuizJ Garcia de Yebenes
Apr 13, 2004·International Clinical Psychopharmacology·Raphael M BonelliHans P Kapfhammer
May 7, 2002·Neuropsychologia·Gilles Lafargue, Angela Sirigu
Apr 5, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jennifer D DavisRaymond P Kesner
Mar 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Jeroen P P van VugtRaymund A C Roos
Mar 23, 2005·Brain and Cognition·Claudine BouletFrancois Richer
May 10, 2001·Ergonomics·J G Phillips, T J Triggs
Apr 28, 2009·Human Movement Science·James G PhillipsFriedemann Müller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Movement Disorders : Official Journal of the Movement Disorder Society
N GeorgiouJ A Bradshaw
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
A CurràA Berardelli
© 2021 Meta ULC. All rights reserved