Bradykinin and protein kinase C activation fail to stimulate renal sensory neurons in hypertensive rats

Hypertension
U C Kopp, L A Smith

Abstract

In normotensive rats, renal sensory receptor activation by increased ureteral pressure results in increased ipsilateral afferent renal nerve activity, decreased contralateral efferent renal nerve activity, and contralateral diuresis and natriuresis, a contralateral inhibitory renorenal reflex response. In spontaneously hypertensive rats (SHR), increasing ureteral pressure fails to increase afferent renal nerve activity. The nature of the inhibitory renorenal reflexes indicates that an impairment of the renorenal reflexes would contribute to the increased efferent renal nerve activity in SHR. We therefore examined whether there was a general decrease in the responsiveness of renal sensory receptors in SHR by comparing the afferent renal nerve activity responses to bradykinin in SHR and Wistar-Kyoto rats (WKY). In WKY, renal pelvic perfusion with bradykinin at 4, 19, 95, and 475 micromol/L increased afferent renal nerve activity by 1066 +/- 704, 2127 +/- 1121, 3517 +/- 1225, and 4476 +/- 1631% x second (area under the curve of afferent renal nerve activity versus time). In SHR, bradykinin at 4 to 95 micromol/L failed to increase afferent renal nerve activity. Bradykinin at 475 micromol/L increased afferent renal nerve activity in...Continue Reading

References

Sep 1, 1992·The American Journal of Physiology·M Colden-StanfieldE K Gallin
May 1, 1992·Canadian Journal of Physiology and Pharmacology·J M WyssW Sripairojthikoon
Jan 1, 1989·Annual Review of Pharmacology and Toxicology·D M Chuang
Nov 1, 1988·Hypertension·J R SowersE T Zawada
Jan 1, 1986·Kidney International·D Schlondorff, R Ardaillou
Jan 1, 1986·Annual Review of Cell Biology·U Kikkawa, Y Nishizuka
Jan 1, 1987·Hypertension·U C KoppG F DiBona
Sep 1, 1993·The American Journal of Physiology·U C Kopp, L A Smith
Dec 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·P A JoseR A Felder
Mar 1, 1993·Hypertension·C ChenM F Lokhandwala
Apr 1, 1993·Journal of Hypertension·M C MichelP A Insel

❮ Previous
Next ❯

Citations

May 5, 2005·Brain Research. Molecular Brain Research·Patrícia Aline BoerJosé Antonio Rocha Gontijo
Nov 21, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C Kopp
Mar 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·John Ciriello
Oct 28, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C Kopp, Michael Z Cicha
Jun 13, 2002·American Journal of Physiology. Renal Physiology·Ming-Chieh MaChau-Fong Chen
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A DendorferP Dominiak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.