Bradykinin antagonists have no analgesic effect on incisional pain.

Anesthesia and Analgesia
Paul A LeonardTimothy J Brennan

Abstract

Bradykinin, an endogenous nonapeptide and an important mediator of inflammation, is also implicated in the initiation and maintenance of pain. Both des-Arg(8), Leu(8)-bradykinin (dALBK) and HOE-140, the prototypic bradykinin B1 and B2 receptor antagonists, respectively, have been shown to reduce pain behaviors and inflammation in animal models of persistent nociception. We studied them for activity against incision-induced pain behaviors in a rat model for postoperative pain. A 1-cm plantar incision was made in the hind paw of halothane-anesthetized rats and closed with 5-0 nylon. Withdrawal responses to punctate and nonpunctate mechanical stimuli were tested with von Frey filaments and a plastic disk attached to a von Frey filament, respectively. Withdrawal latency to radiant heat was also tested. Rats were tested 1 day before the incision, 1 h after the incision, and 0.5, 1, 1.5, and 2.5 h after the injection of the drug. They were then retested at the same times before and after the injection of the drug on each of the first 2 postoperative days. The rats received the saline vehicle dALBK (0.1, 0.3, 1.0, or 3.0 mg/kg) or HOE-140 (0.1, 0.3, 1.0, or 3.0 mg/kg) IV. Another group of rats had the drug injected 1 h before incision...Continue Reading

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Citations

Mar 14, 2009·Regional Anesthesia and Pain Medicine·Joseph M NealQuinn H Hogan
Nov 19, 2009·Regional Anesthesia and Pain Medicine·Brian A WilliamsSteven L Orebaugh
Sep 4, 2010·Regional Anesthesia and Pain Medicine·Simon J ParringtonRichard Brull
Dec 17, 2008·Clinical and Experimental Pharmacology & Physiology·W A Prado, T B Dias
Apr 12, 2005·Drugs·Chester C Buckenmaier, Lisa L Bleckner
Mar 15, 2005·Anesthesiology Clinics of North America·Timothy J BrennanEsther M Pogatzki-Zahn
Apr 15, 2014·International Journal of Pharmaceutics·D E IckowiczC F Weiniger
Jan 31, 2018·Biomolecules & Therapeutics·Seung-In Choi, Sun Wook Hwang
Jul 29, 2011·Anesthesiology·Ina FimerEsther M Pogatzki-Zahn
Sep 9, 2006·Current Opinion in Anaesthesiology·Patricia Lavand'homme
Feb 3, 2018·Pain Reports·Esther M Pogatzki-ZahnStephan A Schug
Oct 24, 2019·Journal of Translational Medicine·Vincent MinvilleJean-Pierre Girolami

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