Bradykinin blocks angiotensin II-induced hypertrophy in the presence of endothelial cells

Hypertension
Rebecca H RitchieR J Schiebinger

Abstract

Angiotensin-converting enzyme inhibitors block left ventricular hypertrophy in vivo. A component of this effect has been attributed to tissue accumulation of bradykinin. Little is known regarding the effect of bradykinin on cardiomyocytes. The objectives of the present study were to define the effects of bradykinin on isolated ventricular cardiomyocytes (from adult and neonatal rat hearts) and to determine the extent to which bradykinin blocks hypertrophy in vitro. Bradykinin was found to be a hypertrophic agonist, as defined by increased protein synthesis and atrial natriuretic peptide secretion and expression. Bradykinin (10 micromol/L) increased [3H]phenylalanine incorporation by 23+/-3% in adult and by 36+/-10% in neonatal cardiomyocytes. Constitutive atrial natriuretic peptide secretion by neonatal myocytes was increased 357+/-103%. All effects of bradykinin were abolished by the B2-kinin receptor antagonist Hoe 140. These increases were similar in magnitude to those observed with phenylephrine (20 micromol/L) and angiotensin II (1 micromol/L). However, in cardiomyocytes cocultured with endothelial cells, bradykinin did not increase protein synthesis. Angiotensin II increased [3H]phenylalanine incorporation by 24+/-3% in a...Continue Reading

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Citations

Feb 15, 2003·European Journal of Pharmacology·Rebecca H RitchieGregory J Dusting
Mar 28, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Julio Gallego-DelgadoJesus Egido
Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·P MenetonF Alhenc-Gelas
Jul 11, 2000·Journal of Molecular and Cellular Cardiology·A C RosenkranzR H Ritchie
Sep 3, 2009·Pharmacology & Therapeutics·Rebecca H RitchieBarbara K Kemp-Harper
Nov 9, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S D HobbsA W Bradbury
Feb 16, 2010·Journal of Molecular and Cellular Cardiology·Monique C de WaardDirk J Duncker
Jan 5, 2005·Biochemical and Biophysical Research Communications·Elangovan VellaichamyKailash N Pandey
Jul 11, 2007·Allergy·M BasG Kojda
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Rebecca H RitchieG J Dusting
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J A SilvaM Bader
Sep 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·L YauP Zahradka
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Apr 13, 1999·The American Journal of Physiology·R H RitchieR J Schiebinger
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Jan 3, 2020·Journal of Vascular Research·César Presto CamposEdwaldo Edner Joviliano

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