PMID: 3747490Jun 1, 1986Paper

Bradykinin causes a prolonged increase in skin microvascular permeability

The Journal of Surgical Research
R J Mullins

Abstract

Bradykinin is an endogenous inflammatory mediator, and its mechanism of action is incompletely understood. It is controversial whether bradykinin causes a sustained increase in microvascular permeability, or has only a transient effect. In anesthetized dogs intraarterial infusion of bradykinin (0.14 to 0.54 micrograms/kg/min) produced an immediate increase in flow of protein-rich, hindpaw lymph. After 210 min of bradykinin infusion lymph flow was threefold greater than baseline, lymph protein concentration remained doubled, and in a dose-related fashion bradykinin produced a sustained increase in lymph protein flux. Lymph flow was then further increased with venous hypertension, and after 4 hr lymph protein flux remained greater from the bradykinin paws than from the control paws. This sustained increase in protein flux indicates that bradykinin produces an increase in permeability at the microvascular membrane by a mechanism that is different from how the initial increase in permeability was produced.

References

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Citations

Nov 17, 2007·The Journal of Investigative Dermatology·Helen E BurrellJames A Gallagher
Jun 1, 2006·Journal of the American College of Surgeons·David S KauvarThomas J Walters
May 1, 1988·The Journal of Surgical Research·G J JurkovichD N Granger
Jul 1, 1995·The Journal of Trauma·P C RidingsH J Sugerman
Aug 1, 1990·Circulation Research·G M SaedA G Scicli
Mar 1, 1995·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·P C RidingsA A Fowler
Jul 7, 2020·Frontiers in Immunology·Sarit PalAnatoliy A Gashev

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