PMID: 8971934Jan 1, 1996Paper

Bradykinin dilates rat middle cerebral artery and its large branches via endothelial B2 receptors and release of nitric oxide

Peptides
C Görlach, M Wahl

Abstract

Ring segments of rat middle cerebral artery (MCA) were prepared for measurement of isometric force and precontracted with 10(-4) M uridine triphosphate (UTP). Concentration-effect curves (CEC) were constructed for bradykinin (BK, 10(-8)(-10)(-1) M) in segments with functionally intact (E+) or denuded (E-) endothelium. E- segments did not dilate to BK. The BK receptor was characterized by application of specific B1 or B2 antagonists [des-Arg4-Leu8] BK (10(-5) M) and [D-Arg4-Hyp3-Thi5-D-Tic7-Oic8] BK (HOE140, 3 x 10(-7) M), respectively, or B2 agonist [des-Arg9] BK (10(-8)-10(-4) M). Involvement of nitric oxide (NO) was tested with NG-nitro-L-arginine (LNNA, 10(-4) M). BK induced concentration-dependent relaxation with a maximal effect (Emax) of 40.86 +/- 1.50% at 10(-4) M and a pD2 (-log10 EC50) of 6.818 +/- 0.044. This relaxation could be prevented with HOE140 or LNNA, but was not influenced by [des-Arg(9)-Leu] BK. [des-Arg9] BK did not induce any effect. These results demonstrate that BK induced relaxation via endothelial B2 receptors and release of NO in isolated rat MCA.

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Citations

Sep 15, 1998·Kidney International. Supplement·C GörlachM Wahl
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Z BenyóM Wahl
Nov 14, 2001·The Journal of Trauma·M RachinskyY Shapira
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W G Mayhan
Sep 24, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Raimund TraboldNikolaus Plesnila
Jan 15, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Matthew J Durand, David D Gutterman
Feb 25, 2014·Clinical Science·Claudio M Costa-NetoLucas T Parreiras-E-Silva
Jan 10, 2008·International Immunopharmacology·Claudio M Costa-NetoPedro P C Souza
Dec 26, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susan Y S FengAdrian M Walker
Jan 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susan Y S FengAdrian M Walker
Jan 6, 2012·Clinical Science·Peter C PapageorgiouJohn S Floras
Nov 13, 2001·British Journal of Pharmacology·J DamasP J Lefebvre
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J E BrianS A Moore
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Zsombor LaczaDavid W Busija
Jun 10, 2017·Pharmacology Research & Perspectives·Vibeke R EriksenMajid Sheykhzade
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A P Willis, C W Leffler
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Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Aug 27, 2021·Journal of Applied Physiology·Frederik Boe HansenUlf Simonsen

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