PMID: 9535152Apr 16, 1998Paper

Bradykinin-induced release of nitric oxide by the isolated perfused rat heart: importance of preformed pools of nitric oxide-containing factors

Journal of Hypertension
A H DanserP R Saxena

Abstract

To study whether the vasorelaxant effect of bradykinin in the coronary vascular bed depends on the release of NO from preformed pools and/or de-novo synthesis of NO resulting from bradykinin-induced stimulation of NO synthase. Rat hearts were perfused according to Langendorff's method. Coronary flow was measured continuously. We constructed concentration-response curves for bradykinin and L-arginine under control conditions, after downregulation of NO synthase by exposing the heart to high concentrations (10 mmol/l) of NO and during chronic inhibition of NO synthase, obtained by perfusing the heart for 30 min with 0.1 mmol/l N(omega)-nitro-L-arginine methyl ester. The effect of acute inhibition of NO synthase was studied by infusing single submaximal doses of bradykinin and of L-arginine in the absence and presence of 0.1 mmol/l N(omega)-nitro-L-arginine methyl ester. Coronary flow [baseline 9 +/- 2 ml/min (mean +/- SD)] increased to maximally 23 +/- 6 ml/min with bradykinin and to 16 +/- 4 ml/min with L-arginine. Maximal coronary flow, established as the maximal effect in response to NO, was 22 +/- 4 ml/min. Chronic inhibition of NO synthase reduced coronary flow to 4 +/- 1 ml/min. Coronary flow did not change after downregula...Continue Reading

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Citations

Feb 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ulrike Kreutzer, Thomas Jue
Sep 14, 2004·Journal of Hypertension·Wendy W BatenburgA H Jan Danser
Oct 13, 2005·Journal of Cardiovascular Pharmacology·Stephen J LewisJames N Bates
Aug 19, 2007·Journal of Cardiovascular Pharmacology·Maleka P Hashmi-HillStephen J Lewis
Feb 10, 2006·Pflügers Archiv : European journal of physiology·Ulrike Kreutzer, Thomas Jue
Aug 2, 2013·The Journal of Pharmacology and Experimental Therapeutics·Muhammad Oneeb Rehman MianErnesto L Schiffrin
Aug 2, 2007·Journal of Cardiovascular Pharmacology·Maleka P Hashmi-HillStephen J Lewis
Apr 7, 2004·British Journal of Pharmacology·Wendy W BatenburgA H Jan Danser
Feb 14, 2006·British Journal of Pharmacology·Erin J WhalenStephen J Lewis
Oct 13, 2005·Journal of Cardiovascular Pharmacology·Stephen J LewisNeil W Kooy
Dec 8, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carla Blum-JohnstonSean M Wilson
Dec 5, 2020·Scientific Reports·James M SecklerStephen J Lewis

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