Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor

American Journal of Physiology. Renal Physiology
Nelly BlaesJean-Pierre Girolami

Abstract

Mesangial matrix expansion is an early lesion leading to glomeruloclerosis and chronic renal diseases. A beneficial effect is achieved with angiotensin I-converting enzyme inhibitors (ACEI), which also favor bradykinin (BK) B2 receptor (B2R) activation. To define the underlying mechanism, we hypothesized that B2R activation could be a negative regulator of collagen synthesis in mesangial cells (MC). We investigated the effect of BK on collagen synthesis and signaling in MC. Inflammation was evaluated by intercellular adhesion molecule-1 (ICAM-1) expression. BK inhibited collagen I and IV synthesis stimulated by high glucose, epithelial growth factor (EGF), and transforming growth factor-β (TGF-β) but did not alter ICAM-1. Inhibition of collagen synthesis was B2R but not B1R mediated. PKC or phosphatidylinositol 3-kinase (PI3K) inhibitors mimicked the BK effect. B2R activation inhibited TGF-β- and EGF-induced Erk1/2, Smad2/3, Akt S473, and EGFR phosphorylation. A phosphatase inhibitor prevented BK effects. The in vivo impact of B2R on mesangial matrix expansion was assessed in streptozotocin-diabetic rodents. Deletion of B2R increased mesangial matrix expansion and albuminuria in diabetic mice. In diabetic rats, matrix expansion...Continue Reading

References

Dec 1, 1992·Human Pathology·A D GlickM A Haralson
May 1, 1991·The American Journal of Physiology·C EmondJ P Girolami
Mar 1, 1993·The American Journal of Physiology·J L BascandsJ P Girolami
May 3, 2000·Kidney International·M W Taal, B M Brenner
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·W HuangF Alhenc-Gelas
Jul 12, 2002·Kidney International·Celine AlricJean-Pierre Girolami
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Eric CellierJean-Pierre Girolami
Feb 1, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Joost P SchanstraJean-Loup Bascands
Dec 20, 2003·Journal of the American Society of Nephrology : JASN·Fuad N Ziyadeh
Apr 17, 2004·Kidney International·Izabella Z A PawluczykKevin P G Harris
Jul 31, 2004·Journal of the American Society of Nephrology : JASN·Fiona T H LeeJosephine M Forbes
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Masao KakokiOliver Smithies
Feb 5, 2005·American Journal of Physiology. Renal Physiology·Yan TanAyad A Jaffa
Apr 29, 2005·Journal of the American Society of Nephrology : JASN·Fiona Y ChowGregory H Tesch
Aug 25, 2005·American Journal of Physiology. Renal Physiology·Susan B GurleyThomas M Coffman
Jan 6, 2006·Journal of the American Society of Nephrology : JASN·Elena Galkina, Klaus Ley
Jun 29, 2007·American Journal of Physiology. Renal Physiology·Yan TanAyad A Jaffa
Aug 30, 2008·Reviews in Endocrine & Metabolic Disorders·Frank C Brosius
Dec 5, 2008·American Journal of Physiology. Renal Physiology·Joseph H GarmanChristine Maric
Dec 17, 2008·Hypertension·Hisko OeseburgAnton J M Roks
Feb 5, 2009·Kidney International·Masao Kakoki, Oliver Smithies
Feb 13, 2009·Journal of the American Society of Nephrology : JASN·Dongcheng WuJoan C Krepinsky
Jun 12, 2009·Kidney International·Sophie BodinNadine Bouby
Sep 5, 2009·Journal of the American Society of Nephrology : JASN·Frank C BrosiusUNKNOWN Animal Models of Diabetic Complications Consortium
Sep 25, 2009·American Journal of Physiology. Renal Physiology·Jin WuFeng Zheng
Sep 26, 2009·Journal of Cellular Physiology·Veronica BovenziFernand Gobeil
Nov 20, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sydney C W TangKar Neng Lai
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Masao KakokiOliver Smithies
Feb 4, 2011·American Journal of Physiology. Renal Physiology·L UttarwarJ C Krepinsky
Mar 5, 2011·Apoptosis : an International Journal on Programmed Cell Death·Seung-Jae KwakShin-Wook Kang

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Citations

Aug 21, 2013·Expert Opinion on Therapeutic Targets·Nelly Blaes, Jean-Pierre Girolami
Jul 3, 2015·Journal of Translational Medicine·Anne Gomez-BrouchetVincent Minville
Aug 23, 2016·Kidney International·Wenjuan LiuZhaoyun Zhang
Jun 28, 2013·International Journal of Molecular Sciences·Hsin-Shan YuChih-Hsin Tang
Mar 20, 2015·Journal of the American Society of Nephrology : JASN·Peiwen WuRong Ma
Jul 17, 2019·Molecular Biology Reports·Mabel CatalánGuillermo Díaz-Araya
May 26, 2017·Current Opinion in Nephrology and Hypertension·Wenjuan LiuZhaoyun Zhang
Jan 28, 2020·American Journal of Physiology. Renal Physiology·Parisa Yazdizadeh ShotorbaniRong Ma
Jul 6, 2019·PloS One·Efrat Shavit-SteinAmir Dori
Jan 25, 2013·Experimental Diabetes Research·Naoaki SakataMichiaki Unno
Oct 24, 2019·Journal of Translational Medicine·Vincent MinvilleJean-Pierre Girolami
Apr 8, 2017·BioMed Research International·Heba El GamalShankar Munusamy

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