Bradykinin mediates the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats

Stroke; a Journal of Cerebral Circulation
J TakadaM Fujishima

Abstract

In patients with stroke and long-standing hypertension, the autoregulation curve of cerebral blood flow (CBF) shifts toward higher blood pressure levels. Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and shift the autoregulation curve back to normal in hypertensive patients. ACE inhibitors have 2 major pharmacological properties: they inhibit both the production of angiotensin II and the breakdown of kinins. Hence, we investigated whether the effect of an ACE inhibitor on the lower limit of CBF autoregulation is mediated by the potentiation of bradykinin-mediated vasodilatation. In 28 male Sprague-Dawley rats, CBF was measured by laser-Doppler flowmetry during stepwise controlled hypotension. The lower limit of CBF autoregulation was defined as the mean arterial pressure at which CBF decreased by 20% of the baseline value. The rats were treated with an ACE inhibitor, captopril, in the captopril group; a bradykinin BK2-receptor antagonist, Hoe140, in the Hoe140 group; and both agents in the captopril+Hoe140 group. Other rats served as a control group. The lower limits of CBF autoregulation were compared among the 4 groups. In the captopril group, the lower limit of CBF autoregulation was 43+/-8 mm Hg (mean...Continue Reading

References

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Citations

Jul 28, 2010·Behavioural Pharmacology·Liga ZvejnieceMaija Dambrova
Oct 3, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken OkamotoMizuo Miyazaki
Dec 2, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junichi TakadaMitsuo Iida
Jan 24, 2015·Expert Review of Neurotherapeutics·Joseph DonnellyMarek Czosnyka
Jun 28, 2007·Expert Opinion on Investigational Drugs·Adriaan A Voors
Dec 12, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sigurdur T SigurdssonSvend Strandgaard
Jul 17, 2007·Progress in Cardiovascular Diseases·Antonio Franco Folino
Jan 19, 2005·British Journal of Pharmacology·François DupuisJean-Marc Chillon
Jan 28, 2006·European Journal of Pharmacology·Sai Wang SetoSai Ming Ngai
Jan 2, 2007·Brain Research·Kazuki OtaMitsuo Iida
Feb 7, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ali Mohammadi-KarakaniMasoud Sotoudeh
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shigeki TsukadaRichard A Rippe
May 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Trine Fischer PedersenSvend Strandgaard

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