PMID: 8954825Nov 1, 1996Paper

Bradykinin metabolism in the liver and lung of the rat

The Journal of Surgical Research
J A GriswoldF J Behal

Abstract

Bradykinin (BK) in an asanguinous salt solution was perfused through intact rat liver. The perfusate was delivered through the portal vein and was collected from the inferior vena cava. BK concentrations varied from 0.0030 to 38.0 microm. The liver had a large capacity to degrade BK and the system did not approach saturation until perfusate BK concentrations reached 60 microm. The quantitatively predominant BK fragments formed and the amount of each formed, expressed as a percentage of the BK degraded during a single transhepatic passage, were Pro-Pro, 74%; Arg-Pro-Pro-Gly-Phe, 15%; and Arg-Pro-Pro-Gly-Phe-Ser-Pro, 7%; the first is indicative of initial aminopeptidase-P cleavage of BK to yield Arg and des-Arg1-BK and the latter two are indicative of initial angiotension converting enzyme (ACE) cleavage of BK. On the other hand, while the perfused rat lung also had a large capacity to degrade BK, the quantitatively predominant BK fragments formed and the amount of each formed, again expressed as a percentage of BK metabolized during a single transpulmonary passage, were Pro-Pro, 47%; Arg-Pro-Pro-Gly-Phe, 35%; and Arg-Pro-Pro-Gly-Phe-Ser-Pro, 7%. Thus in rat liver the aminopeptidase-P pathway is the major route for BK degradation...Continue Reading

Citations

Feb 13, 1999·American Journal of Obstetrics and Gynecology·R M GrimesN L Eriksen
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K M CarvalhoL Juliano
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S TumileroA M Rothschild
Jul 12, 2001·Journal of Hypertension·K J Taylor-McCabeW H Simmons
May 18, 1999·The American Journal of Physiology·S KitamuraA G Scicli
Nov 9, 2000·European Journal of Pharmacology·K BagatéM Barthelmebs
Aug 28, 2003·Archives of Biochemistry and Biophysics·Cağatay ErşahinWilliam H Simmons

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