Abstract
We studied the ability of bradykinin (BK) receptor antagonists type 1 and 2 (B1-RA, B2-RA) to prevent acute inflammation. A peptidoglycan-polysaccharide (PG-APS)-induced model of arthritis in the Lewis rat was analyzed. Four groups of animals were studied for 5 days. Treatment was administered subcutaneously (s.c.) 1 mg/kg every 12 h. Group I received PG-APS and was treated with the B2-RA, CP-0597 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-NChg-Arg). Group II received PG-APS and was treated with a combined B1 and B2-RA, B9430 (DArg-Arg-Pro-Hyp-Gly-Igl-Ser-Dlgl-Oic-Arg). Group III received PG-APS and albumin control. Group IV received albumin control. Joint diameter, liver weight, hematocrit, white blood count and plasma concentrations of prekallikrein, high molecular weight kininogen, HK and IL-beta were measured. Groups were compared by ANOVA. Acute arthritis and hepatomegaly were attenuated in the B2-RA-treated animals (p<0.05). Weight loss was more pronounced in the B1/B2-RA-treated animals. Anemia induced by PG-APS was prevented by B2-RA and B1/B2-RA treatment (p<0.001). A marked decrease in plasma HK to 64% of normal was found in the disease-untreated animals, which was completely normalized by B2-RA treatment and partially attenu...Continue Reading
Citations
Dec 20, 2002·International Immunopharmacology·Irma Isordia-SalasRobert W Colman
Apr 17, 2004·American Journal of Respiratory and Critical Care Medicine·Borja G CosíoIan M Adcock
Jul 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Andrea KochK Fan Chung
Jul 1, 2005·Arthritis Research & Therapy·James C KeithRobert W Colman
Feb 5, 2009·Kidney International·Masao Kakoki, Oliver Smithies
Jul 16, 2008·Molecular Immunology·Cheng-Hung LeeChih-Hsin Tang
Jun 21, 2008·Peptides·Marie-Thérèse BawolakFrançois Marceau
Jul 21, 2015·The Journal of Clinical Investigation·Jenny BjörkqvistThomas Renné
Jan 10, 2008·International Immunopharmacology·U Schulze-TopphoffO Aktas
Aug 28, 2004·The American Journal of Pathology·Ricardo G EspinolaRobert W Colman
Feb 28, 2006·Nutrition·Refaat A F HegaziHossam M Kandil
Oct 2, 2004·Nature Reviews. Drug Discovery·François Marceau, Domenico Regoli
Apr 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Antoni StadnickiRobert W Colman
Apr 18, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Razao IssaKian Fan Chung
Mar 1, 2005·Pharmacological Reviews·L M Fredrik Leeb-LundbergBruce L Zuraw
Jul 5, 2003·Blood·Irma Isordia-SalasRobert W Colman
Aug 16, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Aizhen YangYi Wu
Mar 6, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I M SainzR W Colman
Feb 10, 2016·Biological Chemistry·Yahaira M NaaldijkHenning Ulrich
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Irma Isordia-SalasRobert W Colman
Aug 15, 2018·Frontiers in Immunology·Kerstin GöbelSven G Meuth