Bradykinin regulates cyclooxygenase-2 in rat renal thick ascending limb cells

Hypertension
Jorge A RodriguezNicholas R Ferreri

Abstract

Cyclooxygenase-2 (COX-2) is constitutively expressed in a subset of thick ascending limb cells in the cortex and medulla and increases when the renin-angiotensin and kallikrein-kinin systems are activated. Although the contribution of angiotensin II to the regulation of COX-2 is known, the effects of bradykinin on COX-2 expression have not been determined in this nephron segment. We evaluated expression of B2 bradykinin receptors in thick ascending limb cells containing COX-2 and the effect of bradykinin on COX-2 expression in primary cultured medullary thick ascending cells. The presence of B2 receptors was studied in renal sections by immunohistochemistry with antibodies against B2, COX-2, and Tamm-Horsfall glycoprotein. B2 receptors were detected on the apical and basolateral portion of the thick ascending cells. These cells also contained COX-2, suggesting that COX-2 expression may be regulated via B2 receptor. Incubation of cultured medullary thick ascending cells with bradykinin (10(-7) to 10(-5) mol/L) induced a significant increase on COX-2 protein expression. Maximal expression of COX-2 was observed 4 hours after exposure to bradykinin (10(-7) mol/L), effect abolished by a B2 receptor antagonist (HOE-140; 10(-6) mol/L)...Continue Reading

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Citations

May 25, 2012·American Journal of Physiology. Renal Physiology·Carlos P VioNicholas R Ferreri
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ming-Zhi ZhangRaymond C Harris
Feb 5, 2009·Kidney International·Masao Kakoki, Oliver Smithies
Nov 22, 2011·Prostaglandins & Other Lipid Mediators·Nicholas R FerreriCarlos P Vio
Jun 25, 2013·Journal of Ethnopharmacology·Priscila de SouzaArquimedes Gasparotto
Sep 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jorge A RodriguezVictoria Velarde
Jan 6, 2012·American Journal of Physiology. Renal Physiology·A PaliegeS Bachmann
Aug 30, 2013·American Journal of Physiology. Renal Physiology·Agustin Gonzalez-Vicente, Jeffrey L Garvin
Aug 1, 2014·American Journal of Physiology. Renal Physiology·Shoujin HaoNicholas R Ferreri
Aug 18, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nora HegazyAhmed Fahmy
Aug 3, 2007·American Journal of Physiology. Renal Physiology·Ben EngNicholas R Ferreri

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