PMID: 9174646May 1, 1997Paper

Bradykinin regulates the histamine-induced Ca2+ mobilization via protein kinase C activation in human gingival fibroblasts

Cell Calcium
N NiisatoH Sugiya

Abstract

We previously demonstrated that histamine and bradykinin evoke an increase in intracellular Ca2+ ([Ca2+]i) in human gingival fibroblasts by using a fluorescent Ca2+ indicator Fura-2. In this paper, we further demonstrate the regulation of the histamine-induced Ca2+ mobilization by bradykinin. In fibroblasts stimulated with bradykinin (1 microM), subsequent stimulation with histamine (100 microM) failed to mobilize Ca2+, whereas bradykinin induced an increase in [Ca2+]i in the cells pre-stimulated with histamine. The attenuation of the histamine response was dependent on the concentration of bradykinin for the first stimulation. Histamine also failed to induce the formation of inositol 1,4,5-trisphosphate in fibroblasts pretreated with bradykinin. In fibroblasts pretreated with bradykinin (1 microM) for 3 min and then washed with fresh medium, the effect of histamine on [Ca2+]i quickly returned to the control level. The activation of protein kinase C by phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (PMA) elicited a marked decrease in histamine-induced Ca2+ mobilization. When the protein kinase C activity was inhibited with H7, a protein kinase C inhibitor, or was down-regulated by pretreatment with PMA for 20 h, the inhibi...Continue Reading

References

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Citations

Mar 26, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yorimasa OgataHiroshi Sugiya
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K C LeeC R Jan
Oct 11, 2011·International Immunopharmacology·Gloria Gutiérrez-Venegas, Juan Antonio Arreguín-Cano
May 9, 2012·Biochemical and Biophysical Research Communications·Lukasz SamlukKatarzyna A Nałęcz
Nov 6, 2001·Journal of Receptor and Signal Transduction Research·J S ChengC R Jan

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