PMID: 11345366May 10, 2001Paper

Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors

Journal of the American College of Cardiology
K MinaiMasahiko Kinoshita

Abstract

The goal of this study was to determine: 1) whether bradykinin (BK) directly stimulates tissue plasminogen activator (tPA) secretion in human coronary circulation, and 2) whether angiotensin-converting enzyme (ACE) inhibition favorably alters the fibrinolytic balance regulated by BK. Bradykinin is a potent stimulator of tPA secretion in endothelial cells; however, the effect of BK on tPA release in the human coronary circulation has not been studied. Fifty-six patients with atypical chest pain were randomly assigned to two groups: 25 patients were treated with the ACE inhibitor enalapril (ACE inhibitor group), and 31 were not treated with ACE inhibitors (non-ACE inhibitor group). Graded doses of BK (0.2, 0.6, 2.0 microg/min), acetylcholine (ACh) (30 microg/min) and papaverine (PA) (12 mg) were administered into the left coronary artery. Coronary blood flow (CBF) was evaluated by Doppler flow velocity measurement. Blood samples were taken from the aorta (Ao) and the coronary sinus (CS). Bradykinin induced similar increases in CBF in both groups. The net tPA release induced by BK was dose-dependently increased in both groups, and the extent of that increase in the ACE inhibitor group was greater than that in the non-ACE inhibitor...Continue Reading

References

Nov 16, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·G UrdénB Wiman
Jul 1, 1994·Journal of the American College of Cardiology·R A WrightK A Fox
Dec 1, 1993·The Journal of Clinical Investigation·M NakashimaP M Vanhoutte
May 20, 1993·The American Journal of Cardiology·E O OfiliM J Kern
Aug 4, 1997·The American Journal of Cardiology·W LinzB A Schölkens
Oct 6, 1997·The Journal of Cell Biology·J J EmeisF Lupu
Sep 7, 2000·Cardiovascular Research·C LabinjohD J Webb

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Citations

Apr 9, 2013·Current Heart Failure Reports·Samuel W Joffe, Robert A Phillips
Aug 5, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Roberto FogariGiuseppe Derosa
Nov 3, 2010·Clinical and Experimental Pharmacology & Physiology·Tomohide YoshinoMinoru Horie
Apr 2, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naoto OhiraMinoru Horie
Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuhiro TarutaniMinoru Horie
Jun 6, 2002·British Journal of Clinical Pharmacology·David E Newby, Keith A A Fox
Apr 28, 2012·Pharmacology & Therapeutics·Domenico RegoliFernand Gobeil
Mar 13, 2012·Heart Failure Clinics·Patrick Collier, Kenneth M McDonald
Sep 11, 2007·Journal of Cardiac Failure·Yu-Yu YaoJulie Chao
Nov 26, 2008·Acta Anaesthesiologica Scandinavica·B OsterlundB Biber
Nov 20, 2004·Journal of Thrombosis and Haemostasis : JTH·T HrafnkelsdottirS Jern
Oct 7, 2004·Current Medical Research and Opinion·Michel E Bertrand
Apr 5, 2015·Journal of the American Society of Hypertension : JASH·Clive RosendorffUNKNOWN American Heart Association, American College of Cardiology, and American Society of Hypertension
Jul 8, 2010·Hypertension·Tetsuya MatsumotoUNKNOWN Shiga Plasminogen Activator in Coronary Circulation (SPAIC) Investigators
Apr 2, 2015·Circulation·Clive RosendorffUNKNOWN American Heart Association, American College of Cardiology, and American Society of Hypertension
Mar 8, 2006·Hypertension·Wilhelm RidderstråleThórdís Hrafnkelsdóttir
Apr 14, 2018·Circulation Research·David H WassermanNancy J Brown
Feb 21, 2007·Hypertension·Ana BaracJulio A Panza
Apr 28, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Simon D RobinsonDavid E Newby
Sep 17, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Mias PretoriusNancy J Brown
Oct 8, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·James J OliverDavid E Newby
Apr 2, 2015·Hypertension·Clive RosendorffUNKNOWN American Heart Association, American College of Cardiology, and American Society of Hypertension
Apr 27, 2002·Heart Disease·S A PalkhiwalaS Warshafsky
Mar 19, 2002·Hypertension·Mias PretoriusNancy J Brown
Apr 26, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jan-Arne BjörkmanChristina Jern
Mar 9, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrew J LuckingDavid E Newby
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·David A RosenbaumNancy J Brown
Jan 11, 2007·Drugs·Philip I HairCaroline M Perry
Jun 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·Laine J MurpheyNancy J Brown
Apr 9, 2015·Cardiology in Review·Mark Carpenter, Hannah Sinclair
Dec 1, 2007·European Journal of Gastroenterology & Hepatology·Simone SaibeniMaurizio Vecchi
Jan 2, 2003·The Journal of Physiology·Derek T SmithChristopher A DeSouza
Jan 25, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giulia Dell'OmoRoberto Pedrinelli
Jun 21, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Grant BledsoeJulie Chao

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