PMID: 9435131Jan 22, 1998Paper

Bradyzoite-induced murine toxoplasmosis: stage conversion, pathogenesis, and tissue cyst formation in mice fed bradyzoites of different strains of Toxoplasma gondii

The Journal of Eukaryotic Microbiology
J P Dubey

Abstract

The development of Toxoplasma gondii was studied in mice fed bradyzoites. At one hour after oral inoculation (HAI), bradyzoites were found in cells of the surface epithelium and the lamina propria of the small intestine, primarily the ileum. Division into two tachyzoites was first observed at 18 HAI in the intestine. At 24 HAI, organisms were also seen in mesenteric lymph nodes. Organisms were first detected in the brain at six days after oral inoculation with bradyzoites (DAI) but not consistently until 10 DAI. Immunohistochemical staining with bradyzoite specific (BAG-5 antigen) anti-serum showed that bradyzoites retained their BAG-5 reactivity even after the first division into two tachyzoites in the intestine at 18 HAI. BAG-5 positive organisms were not seen 2-5 DAI. BAG-5 antigens reappeared in T. gondii at 6 DAI. Whole mice and individual tissues of mice fed bradyzoites were bioassayed in cats and mice for the presence of bradyzoites. Feces of cats fed murine tissues were examined for oocyst shedding for short prepatent periods. Bradyzoites were present in the intestines of mice up to 12 HAI but not at 18 HAI, and tachyzoites and not bradyzoites disseminated to other tissues from the intestine. Bradyzoites were again dete...Continue Reading

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Citations

Apr 29, 2005·The Journal of Parasitology·H S BarbosaR M Rodrigues
Jul 9, 2008·The Journal of Parasitology·Travis Quirk, J P Dubey
Feb 11, 2009·Infection and Immunity·Henrik LambertAntonio Barragan
Aug 19, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L David SibleyBenjamin M Rosenthal
Jun 27, 2012·Annals of the New York Academy of Sciences·Caroline M Weight, Simon R Carding
Oct 20, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Miao GuoAbani K Pradhan
Mar 16, 2019·Frontiers in Immunology·Dirk Schlüter, Antonio Barragan
Sep 27, 2019·Frontiers in Cellular and Infection Microbiology·Lisa LuuJanine L Coombes
Sep 16, 2003·Journal of Leukocyte Biology·Dana G Mordue, L David Sibley
Apr 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Joshua B RadkeMichael W White
May 18, 2013·Avian Diseases·Vignesh R PuvanesuaranVenugopal Balakrishnan
Apr 30, 2017·Tissue Barriers·Emily J JonesSimon R Carding
Jun 12, 2018·Schizophrenia Bulletin·Jianchun XiaoRobert H Yolken
Dec 19, 2000·Infection and Immunity·Y W ZhangL M Weiss
Aug 23, 2005·Infection and Immunity·Dawn M WetzelL David Sibley
May 12, 2009·Memórias do Instituto Oswaldo Cruz·David J P Ferguson
Jan 7, 2009·Eukaryotic Cell·Matthew Z AndersonJohn C Boothroyd
Jul 27, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng Wang, Yasuhiro Suzuki
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Janine L CoombesEllen A Robey
Feb 23, 2020·Journal of Cell Science·Maria Fátima HortaThiago Castro-Gomes
May 7, 2020·Frontiers in Cellular and Infection Microbiology·Mizanur RahmanEric Cox
Feb 13, 2020·Mucosal Immunology·Goo-Young SeoMitchell Kronenberg
Feb 28, 2002·The Journal of Infectious Diseases·Oliver Liesenfeld
Dec 4, 2002·Ocular Immunology and Inflammation·Vincent N A Klaren, Aize Kijlstra

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