BRAF mutation is a prognostic biomarker for colorectal liver metastasectomy

Journal of Surgical Oncology
Hao-Wei TengShung-Haur Yang

Abstract

In metastatic colorectal cancer, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is a predictive biomarker for anti-epidermal growth factor receptor (EGFR) treatment and V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a prognostic biomarker. We aimed to determine the impact of KRAS and BRAF mutation as determined from liver metastases specimens on overall survival (OS) in patients following colorectal liver metastasectomy. Liver metastases specimens (n = 292) obtained from patients after liver metastasectomy were used to determine the KRAS/BRAF genotype. Associations between clinicopathological parameters and KRAS/BRAF genotype were identified by univariate and multivariate analyses using the Cox proportional hazards model. The impact of KRAS/BRAF genotype on survival was analyzed using the Kaplan-Meier method. The 5-year survival rate of the cohort was 55.8%. The KRAS and BRAF mutation rates were 38.0 and 2.1%, respectively. BRAF genotype, but not KRAS, was found to be an independent prognostic biomarker (HR = 5.181, P = 0.002) after adjustment for other significant confounding clinicopathological variates: Number of liver metastases (HR = 1.983, P = 0.009), concomitant extrahepatic disease (HR = 1.858, P ...Continue Reading

References

May 20, 1998·Journal of the National Cancer Institute·H J AndreyevP A Clarke
Aug 29, 2002·Nature·Harith RajagopalanVictor E Velculescu
Apr 8, 2004·International Journal of Cancer. Journal International Du Cancer·Jean-Marc FerrazPierre Laurent-Puig
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Milo FrattiniMarco A Pierotti
Feb 23, 2005·Archives of Surgery·Martin SchindlO James Garden
Jul 19, 2005·Cancer Research·Wade S SamowitzMartha L Slattery
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vijay P KhatriJacques Belghiti
Feb 14, 2006·Nature Genetics·Suzanne SchubbertChristian P Kratz
Jan 29, 2008·International Journal of Cancer. Journal International Du Cancer·Ludovic BaraultFrancoise Piard
May 20, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Guoren DengYoung S Kim
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy J FrenchStephen N Thibodeau
Jul 2, 2008·Neoplasia : an International Journal for Oncology Research·Terje AhlquistRagnhild A Lothe
Apr 3, 2009·The New England Journal of Medicine·Eric Van CutsemPhilippe Rougier
Jul 3, 2009·The New England Journal of Medicine·Jolien TolCornelis J A Punt
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan D RichmanPhilip Quirke
Nov 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Youji HeCorrie A M Marijnen
Nov 13, 2009·International Journal of Cancer. Journal International Du Cancer·Inti ZlobecAlessandro Lugli
Dec 17, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnaud D RothFred Bosman
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephan E BaldusHelmut E Gabbert
Apr 29, 2010·British Journal of Cancer·J N Primrose
May 27, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Fariña-SarasquetaA J C van den Brule
Jun 25, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D SantiniA Ruzzo
Jul 16, 2010·The British Journal of Surgery·E J A MorrisG Poston
Feb 10, 2011·Genes, Chromosomes & Cancer·Cecily P VaughnWade S Samowitz
Jun 8, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy J PriceNiall C Tebbutt

❮ Previous
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Citations

Dec 18, 2013·Molecular Diagnosis & Therapy·Cathal P O'BrienStephen P Finn
May 16, 2015·Expert Review of Molecular Diagnostics·Mario ScartozziStefano Cascinu
Mar 22, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L SpeltB Andersson
Jun 27, 2014·Journal of Surgical Oncology·Chun-Chi LinShih-Ching Chang
Jul 25, 2015·The British Journal of Surgery·K W BrudvikJ-N Vauthey
Feb 5, 2014·Journal of Cancer Research and Clinical Oncology·Hsei-Wei WangHao-Wei Teng
Mar 19, 2016·International Journal of Cancer. Journal International Du Cancer·Inger Marie LøesPer Eystein Lønning
Apr 3, 2016·International Journal of Cancer. Journal International Du Cancer·Masakazu HashimotoHideki Ohdan
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianhong PengZhizhong Pan
May 2, 2013·Therapeutic Advances in Medical Oncology·Alexander Stein, Hans-Joachim Schmoll
Mar 27, 2018·The British Journal of Surgery·S YamashitaJ-N Vauthey
Nov 15, 2017·Virchows Archiv : an International Journal of Pathology·Artur MezheyeuskiAnna Portyanko
Apr 13, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carlotta BarbonMatthew J Weiss
Mar 3, 2019·Journal of Surgical Oncology·Yoshikuni KawaguchiJean-Nicolas Vauthey
Jan 23, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hanns C DingesJochen K Lennerz
May 30, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hao-Wei TengSheng-Chieh Huang
Jun 22, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshikuni KawaguchiJean-Nicolas Vauthey
Aug 23, 2020·Current Problems in Cancer·Thiru PrasannaDesmond Yip
May 13, 2021·Journal of Visceral Surgery·H LebrunP Zerbib
Jun 9, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Laurence GauJohan Gagnière
Dec 5, 2017·Current Problems in Surgery·Jeffrey ChakedisTimothy M Pawlik

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