BRAF V600E and SRC mutations as molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer

Scientific Reports
Yoshifumi ShimadaToshifumi Wakai

Abstract

Comprehensive genomic sequencing (CGS) enables us to detect numerous genetic alterations in a single assay. We aimed to identify molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer (CRC) using CGS. One-hundred eleven patients with Stage IV CRC who underwent primary tumor resection were analyzed. We retrospectively investigated genetic alterations using CGS of a 415-gene panel. Clinicopathological variables and genetic alterations were analyzed to identify independent prognostic factors of overall survival (OS). Forty-five of 111 patients had R0 resection; of these, 11 patients underwent conversion surgery. Univariate and multivariate analyses identified histopathological grade 3, R0 resection, BRAF V600E mutation, and SRC mutation as independent prognostic factors for OS (P = 0.041, P = 0.013, P = 0.005, and P = 0.023, respectively). BRAF V600E and SRC mutations were mutually exclusive, and SRC mutation was significantly associated with left-sided tumor and liver metastasis compared to BRAF V600E mutation (P = 0.016 and P = 0.025, respectively). Eleven of the 74 initially unresectable patients underwent conversion surgery for R0 resection, yet none harbored BRAF V600E or SRC mutations...Continue Reading

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Citations

May 16, 2020·Journal of Oncology·Emily L PatonIsabel R Schlaepfer
Dec 31, 2020·BioMed Research International·Taohua YueShanwen Chen
Feb 14, 2021·Genomics, Proteomics & Bioinformatics·Jean-Sébastien MilaneseEdwin Wang
May 13, 2021·Journal of Visceral Surgery·H LebrunP Zerbib
Jul 1, 2021·Computational and Structural Biotechnology Journal·Shujiro OkudaToshifumi Wakai

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