BRAF V600E-mutant colorectal cancers: Where are we?

Bulletin du cancer
Astrid LièvreGérard Lledo

Abstract

The BRAFV600E mutation, observed in 8 % of colorectal cancers (CRC), introduces a particular phenotype and a poor prognosis at the localized or metastatic stage. BRAF mutant CRCs are more often localized in the right colon, poorly differentiated and mucinous. They affect an older population (more often female) and are associated with a more frequent metastatic lymph node and peritoneal evolution. The BRAFV600E mutation is associated with a sporadic microsatellite instability (MSI) status in 20 to 40% of cases. In localized colon cancer, it does not imply any modification of the adjuvant treatment. In metastatic CRC, the first action must be the systematic search for an MSI phenotype, given its frequent association with the presence of a BRAF mutation, in order to propose immunotherapy that has been demonstrated to be very effective in MSI metastatic CRC. In non-MSI CRC, a first-line trichimiotherapy associated with bevacizumab is an option to be favored in patients in good general condition but the association with an anti-EGFR can be discussed, especially when the objective is tumor response. At the same time, surgical resection must be systematically discussed in the case of resectable hepatic metastases since the presence of...Continue Reading

References

Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Aug 29, 2002·Nature·Harith RajagopalanVictor E Velculescu
Nov 26, 2002·Nature Genetics·Pamela M PollockPaul S Meltzer
Jul 7, 2005·Journal of the National Cancer Institute·William L InceHartmut Koeppen
May 15, 2007·Oncogene·M RamanM H Cobb
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federica Di NicolantonioAlberto Bardelli
Jul 3, 2009·The New England Journal of Medicine·Jolien TolCornelis J A Punt
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan D RichmanPhilip Quirke
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemFortunato Ciardiello
Jun 8, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy J PriceNiall C Tebbutt
Mar 27, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Carsten BokemeyerClaus-Henning Köhne
Apr 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kjell Magne TveitThoralf Christoffersen
Mar 12, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A LièvreM Ducreux
Jun 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher G SmithJeremy P Cheadle
Sep 13, 2013·The New England Journal of Medicine·Jean-Yves DouillardScott D Patterson
Oct 22, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F LoupakisA Falcone
Aug 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine VenderboschMiriam Koopman
Oct 23, 2014·The New England Journal of Medicine·Fotios LoupakisAlfredo Falcone
Jan 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rona YaegerLeonard B Saltz
Feb 13, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Filippo PietrantonioSandro Barni
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz
Jul 15, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CremoliniF Pietrantonio
Aug 20, 2015·The New England Journal of Medicine·David M HymanJosé Baselga
Sep 24, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ryan B CorcoranScott Kopetz
Oct 13, 2015·Nature Medicine·Justin GuinneySabine Tejpar
Oct 16, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzLeonard Saltz
Nov 4, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thierry AndréAimery de Gramont
Feb 11, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CremoliniA Falcone
Jul 7, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemD Arnold
Sep 16, 2016·Anticancer Research·Emmanouil PikoulisEfstathios Antoniou
Dec 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chiara CremoliniAlfredo Falcone
Dec 21, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J F SeligmannG Middleton
Feb 20, 2017·Current Treatment Options in Oncology·Romain CohenThierry André

❮ Previous
Next ❯

Citations

Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamed W AttwaAdnan A Kadi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.