Braf V600E mutation in melanoma: translational current scenario

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
J A Guadarrama-OrozcoC Lopez-Camarillo

Abstract

Melanoma was one of the translational cancer examples in clinic, including target therapy related to specific biomarkers impacting in the outcome of melanoma patients. Melanomagenesis involved a wide variety of mutations during his evolution; many of these mutated proteins have a kinase activity. One of the most cited proteins in melanoma is BRAF (about 50-60 % of melanomas harbors activating BRAF mutations), for these the most common is a substitution of valine to glutamic acid at codon 600 (p.V600E). Therefore, the precise identification of this underlying somatic mutation is essential; knowing the translational implications has opened a wide view of melanoma biology and therapy.

References

Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Nov 26, 2002·Nature Genetics·Pamela M PollockPaul S Meltzer
Dec 18, 2003·Journal of the National Cancer Institute·Janet L MaldonadoBoris C Bastian
Mar 24, 2004·Cell·Jan U Lohmann, Detlef Weigel
Mar 24, 2004·Cell·Paul T C WanUNKNOWN Cancer Genome Project
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·Claudia WellbrockRichard Marais
Nov 18, 2005·The New England Journal of Medicine·John A CurtinBoris C Bastian
Sep 16, 2008·Molecular Cancer Therapeutics·Keiran S M SmalleyKatherine L Nathanson
Dec 17, 2009·Journal of the National Cancer Institute·M AnsemsGosse J Adema
Aug 20, 2010·The Journal of Investigative Dermatology·Dominique SchererRajiv Kumar
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Oct 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie A EllerhorstElizabeth A Grimm
Nov 26, 2010·Nature·Cory M JohannessenLevi A Garraway
Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Georgina V LongRichard F Kefford
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Jul 27, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lu SiJun Guo
Feb 24, 2012·The New England Journal of Medicine·Jeffrey A SosmanAntoni Ribas
Apr 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander M MenziesGeorgina V Long
Jul 17, 2012·Cancer Discovery·Kimberly Brown DahlmanWilliam Pao
Oct 2, 2012·The New England Journal of Medicine·Keith T FlahertyJeffrey Weber
Oct 3, 2012·The American Journal of Surgical Pathology·Georgina V LongRichard A Scolyer
Oct 26, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaofeng JiangF Stephen Hodi
Feb 19, 2013·Critical Reviews in Oncology/hematology·Mario Mandalà, Christiane Voit
Jun 21, 2013·The American Journal of Dermatopathology·Maya SaroufimIbrahim Khalifeh
Jul 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine L NathansonGeorgina V Long
Aug 31, 2013·Journal of Translational Medicine·Maria ColombinoGiuseppe Palmieri
Nov 8, 2013·British Journal of Cancer·L HeinzerlingR Schneider-Stock
Nov 10, 2013·Nature Medicine·Piro LitoDavid B Solit

❮ Previous
Next ❯

Citations

Oct 4, 2016·Biochemical and Biophysical Research Communications·Fernanda AntunesSoraya Smaili
Mar 4, 2017·Scientific Reports·Yock Ping ChowVyomesh Patel
Jun 29, 2017·PloS One·Akane YukimoriKei Sakamoto
Jan 19, 2018·Oncology Letters·Silke KuphalAnja Katrin Bosserhoff
Jul 20, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xue BaiLu Si
Nov 12, 2020·International Journal of Molecular Sciences·Aleksandra SimiczyjewDorota Nowak
Jun 21, 2020·Biochemical Pharmacology·Letícia Silva FerrazTiago Rodrigues

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.