PMID: 9534832Apr 16, 1998Paper

Brain 5-HT neurotransmission during paroxetine treatment

The British Journal of Psychiatry : the Journal of Mental Science
P A SargentP J Cowen

Abstract

Animal experimental studies suggest that repeated administration of selective serotonin reuptake inhibitors (SSRIs) produces complex adaptive changes in brain serotonin (5-HT) pathways. The effect of these adaptive changes on different aspects of brain 5-HT neurotransmission and their clinical consequences are not well understood. We studied the effect of repeated administration of the SSRI, paroxetine (20 mg daily), on the cortisol responses to the 5-HT precursor, 5-hydroxytryptophan (5-HTP), in healthy subjects and depressed patients. In healthy subjects, following one week of paroxetine treatment there was a large increase in the cortisol response to 5-HTP. This increase had all but disappeared following 3 weeks treatment. In contrast, in depressed patients treated with paroxetine for 8 weeks, the cortisol response to 5-HTP was significantly increased. SSRI treatment in depressed patients produces a persistent increase in the cortisol response to 5-HTP, a probable measure of neurotransmission at central 5-HT2 receptors. Potentiation of 5-HT2 neurotransmission is unlikely to account for the efficacy of SSRIs in major depression but might underlie their actions in obsessive-compulsive disorder and also perhaps certain of their...Continue Reading

References

Apr 10, 1990·European Journal of Pharmacology·S E Gartside, P J Cowen
Oct 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·C ThompsonS A Checkley
Mar 13, 1995·American Journal of Medical Genetics·S AlonsoJ Demaille
Apr 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·M PiccinelliG Wilkinson
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Jun 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·S Arnott, D Nutt
Jan 1, 1993·Life Sciences·L N Yatham, M Steiner
Jan 1, 1993·Biological Psychiatry·Y KatsudaA L Sharpley
Jan 1, 1991·Journal of Psychopharmacology·J F Deakin, F G Graeff

❮ Previous
Next ❯

Citations

Jun 16, 2005·Neurochemistry International·Magdolna PákáskiJános Kálmán
Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yutaro SuzukiToshiyuki Someya
Mar 5, 2003·Journal of the American Academy of Nurse Practitioners·L Kathleen SekulaVincent Gianetti
Mar 17, 2009·Depression and Anxiety·Joachim CordesAnsgar Klimke
Jun 10, 2011·British Journal of Clinical Pharmacology·Joop van Gerven, Adam Cohen
Mar 5, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob Pr JacobsenMarc G Caron
Sep 16, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S K Srivastava, C Nath
Mar 5, 2008·International Journal of Psychiatry in Medicine·Rhee-Hun KangMin-Soo Lee
Oct 25, 2016·Trends in Pharmacological Sciences·Jacob P R JacobsenMarc G Caron
Aug 23, 2008·Journal of Psychopharmacology·G E JacobsJ M A van Gerven
Apr 30, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jacob P R JacobsenMarc G Caron
Nov 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·R Ramasubbu
Mar 23, 2002·Journal of Clinical Psychopharmacology·Harm J GijsmanAdam F Cohen
Sep 30, 1999·Life Sciences·D K Raap, L D Van de Kar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.