PMID: 2096412Jan 1, 1990Paper

Brain 5-HT1 binding sites in depressed suicides

Psychopharmacology
S C CheethamR W Horton

Abstract

5-HT1 and 5-HT1A binding sites were measured in brain tissue obtained at postmortem from 19 suicides, with definite evidence of depression, and 19 sex and age-matched controls. Thirteen of the depressed suicides had not been prescribed psychoactive drugs recently (drug-free suicides); six had been receiving antidepressant drugs, alone or in combination with other drugs (antidepressant-treated suicides). No significant differences were found in the number or affinity of 5-HT1 and 5-HT1A binding sites in frontal or temporal cortex between drug-free suicides and controls. The number of 5-HT1 sites was significantly lower (by 20%), affinity unaltered, in hippocampus and the affinity significantly lower (by 33%), number unaltered, in amygdala of drug-free suicides than controls. The number of 5-HT1 binding sites tended to be higher and the affinity lower in the antidepressant-treated compared to drug-free suicides, and significantly so in hippocampus. The present results, together with our previous studies, provide no evidence of altered cortical 5-HT markers in depressed suicides, but further emphasise abnormalities in the hippocampus.

References

Jul 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·A CoppenK Wood
Oct 1, 1976·Archives of General Psychiatry·M AsbergP Thorén
Jan 1, 1986·Brain Research·F OwenM Poulter
Nov 20, 1989·Brain Research·S C CheethamG P Reynolds
Oct 1, 1989·Neuropharmacology·S C CheethamR W Horton
Jan 1, 1989·Journal of Neural Transmission. General Section·S C Cheetham, R W Horton
Jul 1, 1987·Journal of Affective Disorders·I G McKeithD Eccleston
Jan 1, 1988·Annual Review of Neuroscience·S J Peroutka
Mar 8, 1988·Brain Research·S C CheethamR W Horton
Dec 1, 1982·Journal of Affective Disorders·H M Van Praag
Aug 1, 1983·Journal of Affective Disorders·C M Banki, M Arató
Dec 1, 1984·Journal of Neurochemistry·J MarcussonB Winblad
Jan 21, 1980·Brain Research·J A HeltzelW H Vogel

❮ Previous
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Citations

Oct 31, 2002·Human Psychopharmacology·John F. Cryan, Brian E. Leonard
Apr 1, 1994·Biological Psychiatry·B ArranzJ Marcusson
May 1, 1996·Pharmacology, Biochemistry, and Behavior·F G GraeffJ F Deakin
Dec 20, 1993·Behavioural Brain Research·F S GuimarãesR T de Almeida
Nov 19, 2003·European Journal of Pharmacology·Klaus Peter LeschLise Gutknecht
May 15, 1997·Biological Psychiatry·B ArranzJ Marcusson
Aug 25, 1999·Biological Psychiatry·M D UnderwoodV Arango
Feb 26, 2003·European Journal of Pharmacology·Miklos Toth
Jun 6, 2003·Neuroscience and Biobehavioral Reviews·Kristine EricksonJay Schulkin
Jul 15, 1998·Neuroscience and Biobehavioral Reviews·R Gross-IsseroffA Weizman
Feb 1, 1997·Journal of Affective Disorders·S LowtherR W Horton
Apr 6, 2001·Neurochemistry International·B N SrinivasK Y Vinod
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Darakhshan J HaleemMohammad A Haleem
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sueli Mendonça NettoFrancisco Silveira Guimarães
Oct 29, 2002·Brain, Behavior, and Immunity·Barry L Jacobs
Aug 30, 2000·Nuclear Medicine and Biology·W C DrevetsC Mathis
Aug 19, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eydie L Moses-KolkoCarolyn C Meltzer
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Laurent Descarries, Mustaph Riad
Jan 30, 2007·Epilepsy Currents·Andres M Kanner
Aug 2, 2005·Epilepsy Currents·Andres M Kanner
Jun 9, 1998·Annals of the New York Academy of Sciences·S E BachusJ E Kleinman
Jun 9, 1998·Annals of the New York Academy of Sciences·C A Stockmeier
Jan 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·P T FrancisD M Bowen
Jun 19, 2004·Reviews in the Neurosciences·E Pretorius
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z SarnyaiM Toth
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
Jul 1, 1992·Journal of Neurochemistry·P S WiddowsonA E Halaris

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