Brain abnormalities in COVID-19 acute/subacute phase: A rapid systematic review

Brain, Behavior, and Immunity
Anna Rita EgbertStephen Karpiak

Abstract

This systematic review aimed to synthesize early data on typology and topography of brain abnormalities in adults with COVID-19 in acute/subacute phase. We performed systematic literature search via PubMed, Google Scholar and ScienceDirect on articles published between January 1 and July 05, 2020, using the following strategy and key words: ((covid[Title/Abstract]) OR (sars-cov-2[Title/Abstract]) OR (coronavirus[Title/Abstract])) AND (brain[Title/Abstract]). A total of 286 non-duplicate matches were screened for original contributions reporting brain imaging data related to SARS-Cov-2 presentation in adults. The selection criteria were met by 26 articles (including 21 case reports, and 5 cohort studies). The data analysis in a total of 361 patients revealed that brain abnormalities were noted in 124/361 (34%) reviewed cases. Neurologic symptoms were the primary reason for referral for neuroimaging across the studies. Modalities included CT (-angiogram, -perfusion, -venogram), EEG, MRI (-angiogram, functional), and PET. The most frequently reported brain abnormalities were brain white matter (WM) hyperintensities on MRI 66/124 (53% affected cases) and hypodensities on CT (additional 23% affected cases), followed by microhemorrha...Continue Reading

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Citations

Feb 10, 2021·Radiology·Jeffrey P KanneNicola Sverzellati
Feb 13, 2021·Neurocritical Care·Brian L EdlowUNKNOWN GCS-NeuroCOVID
Nov 17, 2020·Frontiers in Aging Neuroscience·Silvia Alonso-LanaMercè Boada
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Jul 12, 2021·Radiología·J M Plasencia-MartínezJ J Arenas-Jiménez
Jul 29, 2021·Clinical EEG and Neuroscience·Isabel Sáez-LandeteIgnacio Regidor-BaillyBailliere
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