Brain abscess in a patient with psoriatic arthritis treated with adalimumab: A case report.

Medicine
Yu-Pei LoPo-Yuan Wu

Abstract

In patients receiving biological therapies, serious infections are a major concern. Infections associated with anti-tumor necrosis factor antibody therapy include tuberculosis, viral, fungal, and bacterial infections. Likewise, severe infections of the upper and lower respiratory tract, lung, skin and soft tissue, urinary tract, gastrointestinal tract, joint, and bone have also been reported previously. However, infections involving the central nervous system are rare, especially an intracranial infection caused by odontogenic infection. To date, only few cases have been reported of this infection. This is the first case of a patient with psoriatic arthritis receiving adalimumab and developing brain abscess of odontogenic origin. A 39-year-old male with psoriatic arthritis receiving adalimumab treatment came to the emergency department with initial presentation of sudden onset convulsions. He had been receiving adalimumab treatment for 1 month. Two days after the third injection, the patient had an episode of sudden-onset general convulsion for nearly 5 min with the upgazing and general tonic presentation. Magnetic resonance imaging (MRI) showed left frontal lobe brain abscess. Pus culture from the brain abscess detected Strept...Continue Reading

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Citations

Sep 9, 2020·Expert Opinion on Drug Metabolism & Toxicology·Elisa MolinelliAnnamaria Offidani

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Methods Mentioned

BETA
biopsy

Related Concepts

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Brain Abscess

Brain abscess is an accumulation of pus caused by inflammation and infected materials in the brain. Symptoms include fever, headache, seizures and other neurological problems. Discover the latest research on brain abscess today.

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