Brain activation during disorder-related script-driven imagery in panic disorder: a pilot study.

Scientific Reports
Alexander BurkhardtThomas Straube

Abstract

Despite considerable effort, the neural correlates of altered threat-related processing in panic disorder (PD) remain inconclusive. Mental imagery of disorder-specific situations proved to be a powerful tool to investigate dysfunctional threat processing in anxiety disorders. The current functional magnetic resonance imaging (fMRI) study aimed at investigating brain activation in PD patients during disorder-related script-driven imagery. Seventeen PD patients and seventeen healthy controls (HC) were exposed to newly developed disorder-related and neutral narrative scripts while brain activation was measured with fMRI. Participants were encouraged to imagine the narrative scripts as vividly as possible and they rated their script-induced emotional states after the scanning session. PD patients rated disorder-related scripts as more arousing, unpleasant and anxiety-inducing as compared to HC. Patients relative to HC showed elevated activity in the right amygdala and the brainstem as well as decreased activity in the rostral anterior cingulate cortex, and the medial and lateral prefrontal cortex to disorder-related vs. neutral scripts. The results suggest altered amygdala/ brainstem and prefrontal cortex engagement and point towar...Continue Reading

References

Jan 1, 1986·Behaviour Research and Therapy·D M Clark
Jan 1, 1986·Behaviour Research and Therapy·S ReissR J McNally
Mar 1, 1994·Journal of Behavior Therapy and Experimental Psychiatry·M M Bradley, P J Lang
Apr 1, 1997·Journal of Consulting and Clinical Psychology·N B SchmidtJ H Trakowski
Mar 1, 1997·Journal of Anxiety Disorders·G W KamienieckiG Tsourtos
Apr 15, 1999·Biological Psychiatry·I LiberzonL M Fig
Mar 30, 2000·The American Journal of Psychiatry·J M GormanJ D Coplan
Feb 13, 2001·Journal of Affective Disorders·P J LangA Ohman
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Dec 14, 2001·Neuroreport·A BystritskyS Y Bookheimer
Jul 13, 2002·Biological Psychiatry·Marjolein L BoshuisenJohan A den Boer
Nov 28, 2002·Human Brain Mapping·Richard J MaddockMichael H Buonocore
Feb 1, 2003·Biological Psychiatry·Ruth A LaniusRavi S Menon
Mar 20, 2003·Biological Psychiatry·Ahmad R HaririDaniel R Weinberger
May 2, 2003·Annals of the New York Academy of Sciences·Scott L RauchChristopher I Wright
Aug 30, 2003·Psychophysiology·Bruce N CuthbertMargaret M Bradley
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Dec 9, 2003·Depression and Anxiety·Jennie C I Tsao, Michelle G Craske
Jan 20, 2004·Nature Neuroscience·Hugo D CritchleyRaymond J Dolan
Jan 27, 2004·NeuroImage·Joseph A MaldjianJonathan H Burdette
Mar 5, 2005·The Journal of Neuropsychiatry and Clinical Neurosciences·Lisa A MillerRobin A Hurley
May 4, 2005·Trends in Cognitive Sciences·Kevin N Ochsner, James J Gross
Jun 18, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hans-Ulrich Wittchen, Frank Jacobi
Sep 6, 2005·Biological Psychiatry·Thomas StraubeWolfgang H R Miltner
Dec 1, 2005·The International Journal of Neuropsychopharmacology·Katharina DomschkeJürgen Deckert
Jan 13, 2006·Psychiatry and Clinical Neurosciences·Mitsuru KikuchiYoshifumi Koshino
Apr 6, 2006·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Jun 20, 2006·Biological Psychiatry·Martin P Paulus, Murray B Stein
Oct 4, 2006·Progress in Brain Research·Dean SabatinelliTobias Flaisch
Feb 3, 2007·Human Brain Mapping·Jack L LancasterPeter T Fox
Mar 8, 2007·Behaviour Research and Therapy·Bethany A TeachmanJena Saporito

❮ Previous
Next ❯

Citations

Feb 20, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Renata T OkuroAntonio E Nardi

❮ Previous
Next ❯

Software Mentioned

SPSS
BrainVoyager
Brain Voyager QX
ICBM2tal

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.