Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults

Frontiers in Aging Neuroscience
Chelsea N WongArthur F Kramer

Abstract

Higher cardiorespiratory fitness is associated with better cognitive performance and enhanced brain activation. Yet, the extent to which cardiorespiratory fitness-related brain activation is associated with better cognitive performance is not well understood. In this cross-sectional study, we examined whether the association between cardiorespiratory fitness and executive function was mediated by greater prefrontal cortex activation in healthy older adults. Brain activation was measured during dual-task performance with functional magnetic resonance imaging in a sample of 128 healthy older adults (59-80 years). Higher cardiorespiratory fitness was associated with greater activation during dual-task processing in several brain areas including the anterior cingulate and supplementary motor cortex (ACC/SMA), thalamus and basal ganglia, right motor/somatosensory cortex and middle frontal gyrus, and left somatosensory cortex, controlling for age, sex, education, and gray matter volume. Of these regions, greater ACC/SMA activation mediated the association between cardiorespiratory fitness and dual-task performance. We provide novel evidence that cardiorespiratory fitness may support cognitive performance by facilitating brain activat...Continue Reading

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Citations

Jan 19, 2016·Frontiers in Aging Neuroscience·Udunna C AnazodoKeith S St Lawrence
May 8, 2018·Annals of the New York Academy of Sciences·Chelsea M Stillman, Kirk I Erickson
Dec 26, 2017·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Oron LevinGal Ziv
Jun 5, 2018·Annals of the New York Academy of Sciences·Peter A HallDylan D Wagner
May 24, 2019·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Louis BhererArthur F Kramer
Jul 9, 2020·Perceptual and Motor Skills·Ligita SilineLoreta Stasiule
Sep 6, 2017·Journal of Physical Activity & Health·Nicholas W BaumgartnerNaiman A Khan
Mar 21, 2020·International Journal of Environmental Research and Public Health·Carmen NogueraJosé Manuel Cimadevilla
Aug 4, 2020·Perceptual and Motor Skills·Sarah C DuckworthChristopher G Ballmann
Apr 6, 2019·Frontiers in Psychiatry·Nicole J HegbergScott M Hayes
Oct 26, 2018·Frontiers in Human Neuroscience·Roderik J S Gerritsen, Guido P H Band
Sep 25, 2019·International Journal of Environmental Research and Public Health·Daniel PalacSean P Mullen
Dec 27, 2016·Frontiers in Human Neuroscience·Chelsea M StillmanKirk I Erickson

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Methods Mentioned

BETA
SMA

Software Mentioned

FMRIB
FEAT
SPSS
SPSS21
FMRIB Software Library
MCFLIRT
MELODIC
FSL
FLIRT
FLAME

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