Brain Activation Patterns Associated with the Effects of Emotional Distracters during Working Memory Maintenance in Patients with Generalized Anxiety Disorder

Psychiatry Investigation
Jong-Il ParkJong-Chul Yang

Abstract

Few studies have assessed the neural mechanisms of the effects of emotion on cognition in generalized anxiety disorder (GAD) patients. In this functional MRI (fMRI), we investigated the effects of emotional interference on working memory (WM) maintenance in GAD patients. Fifteen patients with GAD participated in this study. Event-related fMRI data were obtained while the participants performed a WM task (face recognition) with neutral and anxiety-provoking distracters. The GAD patients showed impaired performance in WM task during emotional distracters and showed greater activation on brain regions such as DLPFC, VLPFC, amygdala, hippocampus which are responsible for the active maintenance of goal relevant information in WM and emotional processing. Although our results are not conclusive, our finding cautiously suggests the cognitive-affective interaction in GAD patients which shown interfering effect of emotional distracters on WM maintenance.

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Citations

Jun 22, 2019·Journal of Neural Transmission·Bastiaan GoossenColin van der Heiden
Jun 22, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dennis van der MeerCatharina A Hartman
Jul 25, 2017·Psychological Medicine·C BuffT Straube
May 23, 2019·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Domenico MadonnaPaolo Brambilla
Nov 6, 2020·Social Cognitive and Affective Neuroscience·Nicholas L BalderstonChristian Grillon
Dec 10, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qian CuiHuafu Chen
Aug 24, 2021·Frontiers in Psychiatry·Oday M AbushalbaqMohammad M Herzallah

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Software Mentioned

Statistical Parametric Mapping ( SPM8
SuperLab

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